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安全信息

E0774

Sigma-Aldrich

红霉素

meets USP testing specifications

别名:

Erythromycin A

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About This Item

经验公式（希尔记法）:
C37H67NO13
CAS号:
114-07-8
分子量:
733.93
Beilstein:
75279
EC 号:
204-040-1
MDL编号:
MFCD00084654
UNSPSC代码:
51101500
PubChem化学物质编号:
24894374
NACRES:
NA.76

Agency

USP/NF
meets USP testing specifications

质量水平

200

形式

solid

旋光性

[α]/D -78 to --71°

溶解性

ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

应用

pharmaceutical (small molecule)

作用机制

protein synthesis | interferes

SMILES字符串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

基因信息

human ... ABCB1(5243) , CYP3A4(1576) , MLNR(2862)
mouse ... Abcb1a(18671) , Abcb1b(18669)

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相关类别

一般描述

化学结构：大环内酯

应用

红霉素是一种抗生素，是通过 红霉素链霉菌的某些菌株的生长而产生的。 该产品主要由红霉素A和少量红霉素B和C组成，推荐浓度为100 mg/L。 50至200mg/L的浓度范围也被证明可有效控制细菌的生长。 红霉素已被用作胃动素受体激动剂，以在体外阻断人气道中的呼吸糖结合物分泌， 并可用于质粒固化重组乳酸链球菌MG1363菌株的选择。

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。

注意

该产品在37℃下在溶液中可保持稳定3天。 储备溶液应储存在2-8℃。

制备说明

该产品可以2mg/mL的浓度溶于水中，0.067％的水溶液的pH值为8.0-10.5。 它也可以50mg/mL的浓度溶于乙醇中，获得澄清、无色至淡黄色的溶液。 它易溶于醇、丙酮、氯仿、乙腈和乙酸乙酯中，但会与酸形成盐。 所有溶液应保证避光。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Shrameeta Shinde et al.
Antibiotics (Basel, Switzerland), 10(2) (2021-01-27)
Biofilm, a stress-induced physiological state, is an established means of antimicrobial tolerance. A perpetual increase in multidrug resistant (MDR) infections associated with high mortality and morbidity have been observed in healthcare settings. Multiple studies have indicated that the use of
Saurabh Bhattacharya et al.
Cell reports, 27(2), 334-342 (2019-04-02)
We have previously described the existence of membranous nanotubes, bridging adjacent bacteria, facilitating intercellular trafficking of nutrients, cytoplasmic proteins, and even plasmids, yet components enabling their biogenesis remain elusive. Here we reveal the identity of a molecular apparatus providing a
Christoph Czarnetzki et al.
JAMA surgery, 150(8), 730-737 (2015-06-18)
Patients undergoing emergency procedures under general anesthesia have impaired gastric emptying and are at high risk for aspiration of gastric contents. Erythromycin has strong gastric prokinetic properties. To evaluate the efficacy of erythromycin lactobionate in gastric emptying in patients undergoing
Leena Keurulainen et al.
Journal of medicinal chemistry, 53(21), 7664-7674 (2010-10-12)
Chlamydia pneumoniae is an intracellular bacterium that responds poorly to antibiotic treatment. Insufficient antibiotic usage leads to chronic infection, which is linked to disease processes of asthma, atherosclerosis, and Alzheimer's disease. The Chlamydia research lacks genetic tools exploited by other
Markus Hilleringmann et al.
The EMBO journal, 28(24), 3921-3930 (2009-11-28)
Although the pili of Gram-positive bacteria are putative virulence factors, little is known about their structure. Here we describe the molecular architecture of pilus-1 of Streptococcus pneumoniae, which is a major cause of morbidity and mortality worldwide. One major (RrgB)
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