C8856
卡托普利
meets USP testing specifications
别名:
N-[(S)-3-巯基-2-甲基丙酰基]-L-脯氨酸
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关于此项目
经验公式（希尔记法）:
C9H15NO3S
化学文摘社编号:
分子量:
217.29
Beilstein:
477887
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.21
生物来源
synthetic (organic)
质量水平
Agency
USP/NF
meets USP testing specifications
方案
97.5-102.0% dry basis
表单
crystalline
mp
104-108 °C (lit.)
储存温度
room temp
SMILES字符串
C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
InChI
1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
InChI key
FAKRSMQSSFJEIM-RQJHMYQMSA-N
基因信息
human ... ACE(1636), ECE1(1889)
rat ... Ace(24310)
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生化/生理作用
血管紧张素转换酶抑制剂。抑制血管紧张素 II 的形成，血管紧张素 II 是生物活性多肽，可促进血管生成并增加微血管密度。
警示用语：
Danger
危险声明
危险分类
Muta. 2 - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Peter Vella et al.
Bioorganic & medicinal chemistry letters, 21(11), 3282-3285 (2011-05-04)
The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections. This work describes the discovery of lead compounds for the development of new inhibitors using a
Donna H Lee et al.
American journal of physiology. Cell physiology, 304(2), C147-C163 (2012-11-02)
The renal distal tubule Na-Cl cotransporter (NCC) reabsorbs <10% of the filtered Na(+) but is a key control point for blood pressure regulation by angiotensin II (ANG II), angiotensin-converting enzyme inhibitors (ACEI), and thiazide diuretics. This study aimed to determine
Wenna Zhao et al.
Journal of ethnopharmacology, 145(1), 187-192 (2012-11-13)
ETHNOPHARMACOLOGICA RELEVANCE: Picrasma quassiodes (D. Don) Benn. (PQB) is a widely used herbal medicine used for gastroenteritis, snakebite, infection and hypertension in China. The aim of the study was to investigate the possible antihypertensive mechanisms on spontaneously hypertensive rats (SHR)
Faridoon et al.
Bioorganic & medicinal chemistry letters, 22(1), 380-386 (2011-11-26)
The production of β-lactamases is an effective strategy by which pathogenic bacteria can develop resistance against β-lactam antibiotics. While inhibitors of serine-β-lactamases are widely used in combination therapy with β-lactam antibiotics, there are no clinically available inhibitors of metallo-β-lactamases (MBLs)
Samir Attoub et al.
Annals of the New York Academy of Sciences, 1138, 65-72 (2008-10-08)
Lung cancer is the most common form of cancer in the world, and 90% of patients die from their disease. The angiotensin converting enzyme (ACE) inhibitors are used widely as antihypertensive agents, and it has been suggested that they decrease
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