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Merck
CN

C8037

丙酸氯倍他索

analytical standard

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关于此项目

经验公式（希尔记法）:
C25H32ClFO5
化学文摘社编号:
25122-46-7
分子量:
466.97
NACRES:
NA.24
PubChem Substance ID:
329775158
UNSPSC Code:
41116107
EC Number:
246-634-3
MDL number:
MFCD00058499

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产品名称

丙酸氯倍他索, analytical standard

InChI key

CBGUOGMQLZIXBE-XGQKBEPLSA-N

InChI

1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1

SMILES string

CCC(=O)O[C@@]1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)CCl

grade

analytical standard

assay

≥98%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... NR3C1(2908)
rat ... Nr3c1(24413)

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相关类别

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Clobetasol propionate is a novel and highly potent, topical corticosteroid, which is being assessed for its utility in the treatment of bullous pemphigoid.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B - STOT RE 2

target_organs

Adrenal gland,Immune system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF5836V
WXBF3427V
WXBF2638V
WXBF0008V
WXBD9233V

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Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases.
Lozada-Nur F and Huang M Z
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 71(3), 283-287 (1991)
Open preliminary clinical trial of clobetasol propionate ointment in adhesive paste for treatment of chronic oral vesiculoerosive diseases
Lozada-Nur F, et al.
Oral Surgery, Oral Medicine, and Oral Pathology, 71, 283-287 (1991)
Treatment of bullous pemphigoid with topical clobetasol propionate
Westerhof W
Journal of the American Academy of Dermatology, 20, 458-461 (1989)
Treatment of bullous pemphigoid with topical clobetasol propionate.
Westerhof W.
Journal of the American Academy of Dermatology, 20(3), 458-461 (1989)
Mark G Lebwohl et al.
Journal of the American Academy of Dermatology, 69(3), 385-392 (2013-05-07)
Few clinical trials have evaluated the combination of topical corticosteroids plus systemic therapies for psoriasis. We sought to evaluate efficacy and safety of etanercept plus topical clobetasol propionate (CP) foam versus etanercept monotherapy for treatment of moderate to severe plaque
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