推荐产品
生物来源
synthetic (chemical)
质量水平
方案
89.0-100.5% anhydrous basis
表单
powder
颜色
white to off-white
溶解性
H2O: 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
cell wall synthesis | interferes
储存温度
2-8°C
SMILES字符串
[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)C(C([O-])=O)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
InChI
1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25);;/q;2*+1/p-2/t9?,10-,11+,14-;;/m1../s1
InChI key
RTYJTGSCYUUYAL-YCAHSCEMSA-L
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一般描述
羧苄青霉素是一种半合成、广谱羧基青霉素抗生素，具有杀菌和抗β－内酰胺酶活性。它是一种广谱抗生素，即它能够有效对抗各种细菌，包括革兰氏阳性和革兰氏阴性细菌。羧苄青霉素对铜绿假单胞菌特别有效，铜绿假单胞菌是一种可以耐受其它抗生素的革兰氏阴性菌。
羧苄青霉素常用于细胞生物学应用，可防止细菌污染物的生长。在微生物学中，它也用于选择以含有编码β－内酰胺酶基因的载体转化的细菌，这使其耐受羧苄青霉素。
羧苄青霉素常用于细胞生物学应用，可防止细菌污染物的生长。在微生物学中，它也用于选择以含有编码β－内酰胺酶基因的载体转化的细菌，这使其耐受羧苄青霉素。
应用
羧苄青霉素二钠盐已用于：
- 制备LB琼脂平板和培养基
- 作为培养基中的选择剂用于防止细菌污染物的生长
- 开发单克隆抗体的研究
生化/生理作用
羧苄青霉素通过打开内酰胺环，酰化青霉素敏感性转肽酶（penicillin-sensitive transpeptidase）的C-末端结构域。这种钝化作用防止了肽聚糖束（peptidoglycan strand）的交联，从而抑制了细菌细胞壁合成的第三和最后阶段。这导致细菌细胞壁的不完全合成，最终导致细胞溶解。
作用机制：羧青霉素抗生素，可通过灭活细菌细胞膜内表面的转肽酶来抑制细菌细胞壁合成（肽聚糖交联）。
抗微生物谱：具有抗革兰氏阳性和革兰氏阴性细菌活性。
抗微生物谱：具有抗革兰氏阳性和革兰氏阴性细菌活性。
特点和优势
- 具有杀菌和抗β－内酰胺酶活性的广谱抗生素
- 有效对抗各种细菌，包括铜绿假单胞菌
- 常用于细胞生物学和生物化学应用
- 提供优于氨苄青霉素的稳定性
储存及稳定性
Tightly closed. Dry. Keep locked up or in an area accessible only to qualified or authorized
分析说明
在 37°C 下可稳定保存 3 天
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
监管及禁止进口产品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Sua Lee et al.
Frontiers in immunology, 12, 778829-778829 (2021-12-07)
Since the coronavirus disease outbreak in 2019, several antibody therapeutics have been developed to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. Antibody therapeutics are effective in neutralizing the virus and reducing hospitalization in patients with mild and moderate
Boris Rodenko et al.
Nature protocols, 1(3), 1120-1132 (2007-04-05)
Major histocompatibility complex (MHC) class I molecules present peptide ligands on the cell surface for recognition by appropriate cytotoxic T cells. MHC-bound peptides are critical for the stability of the MHC complex, and standard strategies for the production of recombinant
Tommaso Biancalani et al.
Molecular systems biology, 15(6), e8707-e8707 (2019-06-13)
Quantifying virulence remains a central problem in human health, pest control, disease ecology, and evolutionary biology. Bacterial virulence is typically quantified by the LT50 (i.e., the time taken to kill 50% of infected hosts); however, such an indicator cannot account
Gina M Geiselman et al.
Microbial cell factories, 19(1), 24-24 (2020-02-07)
Rhodosporidium toruloides has emerged as a promising host for the production of bioproducts from lignocellulose, in part due to its ability to grow on lignocellulosic feedstocks, tolerate growth inhibitors, and co-utilize sugars and lignin-derived monomers. Ent-kaurene derivatives have a diverse
Edward Avilés et al.
Organic letters, 12(22), 5290-5293 (2010-10-23)
Monamphilectine A (1), a new diterpenoid β-lactam alkaloid showing potent antimalarial activity, was isolated in milligram quantities following bioassay-directed extraction of a Puerto Rican marine sponge Hymeniacidon sp. Its structure, established by interpretation of spectral data, was confirmed unequivocally by
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