推荐产品
等级
analytical standard
质量水平
产品线
PESTANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
162-164 °C (lit.)
应用
agriculture
environmental
包装形式
neat
SMILES字符串
CC(=O)CC(c1ccccc1)C2=C(O)c3ccccc3OC2=O
InChI
1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3
InChI key
PJVWKTKQMONHTI-UHFFFAOYSA-N
基因信息
human ... VKORC1(79001)
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应用
华法林是一种常用于预防血栓形成和血栓栓塞的抗凝剂。 其已在许多中风和肺纤维化患者研究中使用。 它已用于研究潜在风险以及与其他药物和食物的相互作用。
有关合适的仪器技术的更多信息，请参阅产品的分析证书。想要获得更多支持，请联系技术服务部。
生化/生理作用
华法林由两种活性对映体R和S形式的外消旋混合物组成。 华法林比普通抗凝肝素作用慢。 华法令可抑制钙依赖性凝血因子II、VII、IX和X的生物活性形式的维生素K依赖性合成。它可抑制调节因子蛋白C、蛋白S和蛋白Z。
注意
仅限于专业用户。注意 — 避免接触 — 使用前请阅读说明书。
法律信息
PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Repr. 1A - STOT RE 1 Oral
靶器官
Blood
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
法规信息
危险化学品
农药列管产品
Jack Ansell et al.
Chest, 126(3 Suppl), 204S-233S (2004-09-24)
This article concerning the pharmacokinetics and pharmacodynamics of vitamin K antagonists (VKAs) is part of the Seventh American College of Chest Physicians Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines. The article describes the antithrombotic effect of VKAs, the monitoring
A Placebo-Controlled Randomized Trial of Warfarin in Idiopathic Pulmonary Fibrosis
Imre Noth, Kevin J. Anstrom, et al.
American Journal of Respiratory and Critical Care Medicine, 10.1164, 201202-03140C-201202-03140C (2012)
Daisuke Yoshioka et al.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 17(4), 308-314 (2014-07-23)
The aim of this study was to evaluate our clinical experience with the Jarvik 2000 axial flow pump (Jarvik Heart, Inc, New York, NY, USA), a miniature axial flow left ventricular assist device (LVAD). The clinical results of eight patients
Periprocedural management of new oral anticoagulants in patients undergoing atrial fibrillation ablation.
Jeffrey I Weitz et al.
Circulation, 129(16), 1688-1694 (2014-04-23)
James D Douketis et al.
Thrombosis and haemostasis, 113(3), 625-632 (2014-12-05)
In patients with atrial fibrillation (AF) who require interruption of dabigatran or warfarin for an elective surgery/procedure, the risks and benefits of perioperative bridging anticoagulation is uncertain.We accessed the database from RE-LY, a randomised trial comparing dabigatran with warfarin for
实验方案
HPLC Analysis of Warfarin™ Anticoagulant on Ascentis® C18
Chromatograms
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