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等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InChI
1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
InChI key
TTWJBBZEZQICBI-UHFFFAOYSA-N
基因信息
human ... DRD2(1813) , HTR3A(3359) , HTR4(3360)
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一般描述
Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.
Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.
应用
Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.
Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 1
Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection.
Vlase L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(3), 652-657 (2007)
RP?HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies.
Lamparczyk H, et al.
Biomedical Chromatography, 15(8), 513-517 (2001)
Pharmacovigilance in hospice/palliative care: rapid report of net clinical effect of metoclopramide.
David C Currow et al.
Journal of palliative medicine, 15(10), 1071-1075 (2012-08-01)
Understanding the performance of prescribed medications in day-to-day practice is important to minimize harm, maximize clinical benefits, and, eventually, better target the people who are most likely to benefit, especially in hospice/palliative care where there may be limited time to
Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide.
Aapro SM, et al.
Journal of Clinical Oncology, 2(5), 466-471 (1984)
P Jay Pasricha et al.
Nature clinical practice. Gastroenterology & hepatology, 3(3), 138-148 (2006-03-03)
Metoclopramide, the only drug approved by the FDA for treatment of diabetic gastroparesis, but used off-label for a variety of other gastrointestinal indications, has many potentially troublesome adverse neurologic effects, particularly movement disorders. In this article, we comprehensively review the
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