32473
甲氧氯普胺
VETRANAL®, analytical standard
别名:
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide, Methoxychloroprocainamide
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经验公式（希尔记法）:
C14H22ClN3O2
化学文摘社编号:
分子量:
299.80
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
206-662-9
Beilstein/REAXYS Number:
1884366
MDL number:
产品名称
甲氧氯普胺, VETRANAL®, analytical standard
format
neat
InChI
1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
InChI key
TTWJBBZEZQICBI-UHFFFAOYSA-N
SMILES string
CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
storage temp.
2-8°C
Quality Level
Gene Information
human ... DRD2(1813), HTR3A(3359), HTR4(3360)
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Application
Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.
Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.
Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
Determination of loratadine and its active metabolite in human plasma by high-performance liquid chromatography with mass spectrometry detection.
Vlase L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 44(3), 652-657 (2007)
G S De Oliveira et al.
British journal of anaesthesia, 109(5), 688-697 (2012-09-28)
Previous evidence suggested that 10 mg systemic metoclopramide is not effective to prevent postoperative nausea and/or vomiting (PONV) in patients receiving general anaesthesia. However, the evidence included data with questioned validity by the author Yoshitaka Fujii. The objective of the
Pharmacovigilance in hospice/palliative care: rapid report of net clinical effect of metoclopramide.
David C Currow et al.
Journal of palliative medicine, 15(10), 1071-1075 (2012-08-01)
Understanding the performance of prescribed medications in day-to-day practice is important to minimize harm, maximize clinical benefits, and, eventually, better target the people who are most likely to benefit, especially in hospice/palliative care where there may be limited time to
RP?HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies.
Lamparczyk H, et al.
Biomedical Chromatography, 15(8), 513-517 (2001)
Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide.
Aapro SM, et al.
Journal of Clinical Oncology, 2(5), 466-471 (1984)
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