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17850

Sigma-Aldrich

环丙沙星

≥98% (HPLC)

别名:

1-环丙基-6-氟-4-氧代-7(1-哌嗪基)-1,4-二氢喹啉-3-羧酸, 西普乐

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About This Item

经验公式（希尔记法）:
C17H18FN3O3
CAS号:
85721-33-1
分子量:
331.34
Beilstein:
3568352
MDL编号:
MFCD00185755
UNSPSC代码:
41116105
PubChem化学物质编号:
329751572
NACRES:
NA.21

Agency

EPA 1694

质量水平

200

方案

≥98% (HPLC)

表单

powder or crystals

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

应用

environmental

作用机制

DNA synthesis | interferes
enzyme | inhibits

SMILES字符串

OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O

InChI

1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)

InChI key

MYSWGUAQZAJSOK-UHFFFAOYSA-N

基因信息

human ... CYP1A2(1544) , KCNH1(3756)
rat ... Gabra1(29705)

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相关类别

一般描述

环丙沙星是第二代广谱氟喹诺酮抗生素，具有广泛抗菌性和药动学特征，广泛用于对抗细菌感染。化学名称是1-环丙基-6-氟-4-氧代-7-(哌嗪-1-基)-1,4-二氢喹啉-3-羧酸。

化学结构：氟喹诺酮

应用

环丙沙星在临床中广泛用于对付革兰阳性和阴性菌，治疗皮肤、眼睛、泌尿道、下呼吸道、胃肠道等多个部位的感染。 还可联合多种抗菌药物对抗细菌生物膜和多重耐药微生物。另外，开发的衍生物可合成新型抗菌药物，疗效增强且具有抗菌、抗真菌、抗HIV、抗肿瘤和抗TB等各种抗微生物活性。

生化/生理作用

环丙沙星的作用机制是 通过抑制DNA促旋酶(gyrase)和影响细菌细胞壁来抑制细菌DNA合成 。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000369395
0000369394
0000340340
0000369395
0000369394

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the solubility of Product 17850, Ciprofloxacin?

    17850 is the free base of ciprofloxacin. It is soluble in 0.1N HCl at 25 mg/ml.  Ciprofloxacin is poorly soluble in DMSO. For HPLC, dissolve the sample material in a mixture ofAcetonitril/Phosphoric acid pH 2.4 by ultrasonification (5 mg/10 ml solvent).

  4. Can Product 17850, Ciprofloxacin, be used in cell culture?

    We have not done cell culture testing with this product.

  5. What is the potency of Product 17850, Ciprofloxacin?

    The potency of this product has not been determined by our Quality Control or by our supplier.

  6. Can Product 17850, Ciprofloxacin, be used to remove Mycoplasma contaminations?

    We have not tested the product for that application. However, there is a reference in Roche's Biochemica Newsletter Issue 1 from 1996 that describes using Ciprofloxacin in mycoplasma contamination.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Gui-Fu Zhang et al.
European journal of medicinal chemistry, 146, 599-612 (2018-02-07)
Bacterial infections represent a significant health threat globally, and are responsible for the majority of hospital-acquired infections, leading to extensive mortality and burden on global healthcare systems. The second generation fluoroquinolone ciprofloxacin which exhibits excellent antimicrobial activity and pharmacokinetic properties
The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic
Shariati et al.
Frontiers in public health, 10 (2022)
Athina Andrea et al.
Microorganisms, 7(3) (2019-03-22)
Among non-mammalian infection model organisms, the larvae of the greater wax moth Galleria mellonella have seen increasing popularity in recent years. Unlike other invertebrate models, these larvae can be incubated at 37 °C and can be dosed relatively precisely. Despite
Orjan Samuelsen et al.
Antimicrobial agents and chemotherapy, 54(1), 346-352 (2009-11-04)
Scandinavia is considered a region with a low prevalence of antimicrobial resistance. However, the number of multidrug-resistant (MDR) Gram-negative bacteria is increasing, including metallo-beta-lactamase (MBL)-producing Pseudomonas aeruginosa. In this study MBL-producing P. aeruginosa isolates identified in Norway (n = 4)
Dongeun Yong et al.
Antimicrobial agents and chemotherapy, 53(12), 5046-5054 (2009-09-23)
A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex. The isolate, Klebsiella pneumoniae 05-506, was shown to
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