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Merck
CN
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安全信息

06734

Supelco

泰莫西芬

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

别名:

(Z)-1-(对二甲基氨基乙氧基苯基)-1,2-二苯基-1-丁烯, (Z)-2-[4-(1,2-二苯基-1-丁烯)苯氧基]-N,N-二甲基乙胺

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About This Item

线性分子式:
C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2
CAS号:
10540-29-1
分子量:
371.51
EC 号:
234-118-0
MDL编号:
MFCD00010454
UNSPSC代码:
41116107
PubChem化学物质编号:
329748268
NACRES:
NA.24

等级

certified reference material
TraceCERT®

质量水平

300

产品线

TraceCERT®

保质期

limited shelf life, expiry date on the label

制造商/商品名称

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

储存条件

under inert gas (Argon)

技术

gas chromatography (GC): suitable

mp

97-98 °C (lit.)

包装形式

neat

储存温度

2-8°C

SMILES字符串

CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCN(C)C)cc3

InChI

1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-

InChI key

NKANXQFJJICGDU-QPLCGJKRSA-N

基因信息

human ... ESR1(2099)

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相关类别

一般描述

该认证标准物质（CRM）根据ISO/IEC 17025和ISO 17034生产和认证。 该CRM可追溯来自NMI的原始材料，如NIST或NMIJ。
NMR定量信息已包括在认证内容中。证书上已给出不确定性和失效日期。
证书下载网址：http://www.sigma-aldrich.com

生化/生理作用

蛋白激酶 C 抑制剂。诱发人类恶性神经胶质瘤细胞系的细胞凋亡。他莫昔芬及其代谢产物 4-羟基他莫昔芬是选择性雌激素反应调节剂 (SERM)，在乳腺中用作雌激素拮抗剂。阻止乳腺肿瘤细胞中雌二醇刺激的 VEGF 的产生。

法律信息

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

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象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Danger

危险声明

H350,H360,H410

预防措施声明

P201 - P273 - P308 + P313

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

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分析证书(COA)

Lot/Batch Number
BCCL5756
BCCF5295
BCCC5528
BCBS1827V

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.
Shiau A K, et al.
Cell, 95(7), 927-937 (1998)
Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14.
Fisher B, et al.
Journal of the National Cancer Institute, 86(7), 527-537 (1994)
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Action-outcome associations depend on prefrontal cortex (PFC) projections to the dorsal striatum. To assess how these projections form, we measured PFC axon patterning, synapse formation, and functional maturation in the postnatally developing mouse striatum. Using Hotspot analysis, we show that
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Wenxia Zhao et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11(15), e2306472-e2306472 (2024-02-12)
Myofibrillogenesis regulator-1 (MR-1) is a multifunctional protein involved in the development of various human tumors. The study is the first to report the promoting effect of MR-1 on the development and metastasis of non-small cell lung cancer (NSCLC). MR-1 is
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