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一般描述
转铁蛋白是一种血清糖蛋白，参与铁从吸收和储存部位向组织细胞的转运过程。铁结合的转铁蛋白，也称为铁结合转铁蛋白，可与生长细胞上的特定细胞表面受体结合，并被内吞作用内化。进入细胞后，铁被释放到细胞中，无铁转铁蛋白（也称为脱铁转铁蛋白）则通过胞吐作用释放到细胞外，而不会被降解。
应用
转铁蛋白与胰岛素类似，是大多数无血清培养基配方的一种组分。转铁蛋白的主要功能是通过受体介导的内吞作用将铁转运到细胞中。
来自人血清的转铁蛋白可用作以下产品的补充剂：
来自人血清的转铁蛋白可用作以下产品的补充剂：
- 分化培养基
- 角质形成细胞培养基
- 造血内皮细胞培养基
- 拟胚体培养基
- 原始菌落形成细胞培养基
外形
溶液，30mg/ml，溶于IMDM中，已通过0.2 μm孔径滤膜过滤。铁饱和度低于1％。该产品为脱铁转铁蛋白。
制备说明
工作浓度：1至100μg/ml
储存及稳定性
2至8 °C储存。（冻干粉和溶液）
其他说明
仅用于生命科学研究。不可用于诊断。
WGK
WGK 1
闪点(°F)
No data available
闪点(°C)
No data available
法规信息
常规特殊物品
Özge Vargel et al.
Scientific reports, 6, 21518-21518 (2016-02-20)
The endothelial to haematopoietic transition (EHT) is a key developmental process where a drastic change of endothelial cell morphology leads to the formation of blood stem and progenitor cells during embryogenesis. As TGFβ signalling triggers a similar event during embryonic
Quantification of Mouse Hematopoietic Progenitors? Formation Using Time-lapse Microscopy and Image Analysis
Bergiers I, et al.
Bio-protocol, 9(1), e3137-e3137 (2019)
Iron deficiency affects early stages of embryonic hematopoiesis but not the
endothelial to hematopoietic transition.
endothelial to hematopoietic transition.
Shvartsman M, et al.
bioRxiv (2018)
Zhiru Guo et al.
Journal of visualized experiments : JoVE, (49)(49), doi:10-doi:10 (2011-04-15)
The homeostasis of all self-renewing tissues is dependent on adult stem cells. As undifferentiated stem cells undergo asymmetric divisions, they generate daughter cells that retain the stem cell phenotype and transit-amplifying cells (TA cells) that migrate from the stem cell
A Dautry-Varsat et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(8), 2258-2262 (1983-04-01)
At pH 5.4 apotransferrin (iron-free transferrin) binds to cell-surface transferrin receptors to the same extent and with the same affinity as does diferric transferrin at pH 7.0. Apotransferrin is quickly dissociated from its receptor when the pH is raised to
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