产品名称
抗-BRCA1（Ab-1）小鼠mAb（MS110）, liquid, clone MS110, Calbiochem®
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
MS110, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
dilution
(Frozen Sections
Immunoblotting (2 µg/mL)
Immunofluorescence
Immunoprecipitation
Paraffin Sections )
isotype
IgG1
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BRCA1(672)
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
根据美国专利号5,753,441和6,162,897的许可证销售。
Analysis Note
阳性对照
MCF7细胞
MCF7细胞
Application
冰冻切片（见应用参考文献）
免疫印迹（2 µg/ml）
免疫荧光（见应用参考文献）
免疫沉淀（见应用参考文献）
石蜡切片（见应用参考文献）
免疫印迹（2 µg/ml）
免疫荧光（见应用参考文献）
免疫沉淀（见应用参考文献）
石蜡切片（见应用参考文献）
Disclaimer
毒性：标准处理（A）
General description
可识别MCF-7细胞中的~220 kDa BRCA1蛋白。不与血型抗原或生长因子受体（如EGFR）发生交叉反应。根据美国专利号5,753,441和6,162,897的许可证销售。
抗BRCA1（Ab-1），小鼠单克隆，克隆MS110，可识别MCF-7细胞中的~220 kDa BRCA1蛋白。它经过验证可用于冷冻和石蜡切片的WB、IF、IP分析。
通过用指定的免疫原免疫小鼠并将脾细胞与NS1小鼠骨髓瘤细胞融合而产生的纯化小鼠单克隆抗体。可识别~220 kDa BRCA1蛋白。
Immunogen
人
表位：BRCA1的N末端304个氨基酸内
重组人BRCA1
Other Notes
Scully, R., et al. 1996.Science272, 123.
Gudas, J.M., et al. 1996.Cell Growth Differ.7, 717.
Vaughn, J.P., et al. 1996.Cell Growth Differ.7, 711.
Goldgar, D.E. and Reilly, P.R.1995.Nat. Genet.11, 113.
Merajver, S.D., et al. 1995.Clin. Can.Res.1, 539.
Merajver, S.D., et al. 1995.Nat. Genet.9, 439.
Struewing, J.P., et al. 1995.Nat. Genet.11, 198.
Thompson, M.E., et al. 1995.Nat. Genet.9, 444.
Futreal, P.A., et al. 1994.Science266, 120.
Miki, Y., et al. 1994.Science266, 66.
Wilson, C.A., et al. 1999.Nat. Genet.21, 236.
Gudas, J.M., et al. 1996.Cell Growth Differ.7, 717.
Vaughn, J.P., et al. 1996.Cell Growth Differ.7, 711.
Goldgar, D.E. and Reilly, P.R.1995.Nat. Genet.11, 113.
Merajver, S.D., et al. 1995.Clin. Can.Res.1, 539.
Merajver, S.D., et al. 1995.Nat. Genet.9, 439.
Struewing, J.P., et al. 1995.Nat. Genet.11, 198.
Thompson, M.E., et al. 1995.Nat. Genet.9, 444.
Futreal, P.A., et al. 1994.Science266, 120.
Miki, Y., et al. 1994.Science266, 66.
Wilson, C.A., et al. 1999.Nat. Genet.21, 236.
在单个系统中，应对抗体进行滴定以获得最佳结果。
Packaging
请参考特定浓度批号的标签。
Physical form
溶于50 mM磷酸钠缓冲液（pH 7.5），含0.2％明胶。
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
J Xu et al.
International journal of oncology, 34(4), 939-949 (2009-03-17)
BRCA1 dysfunction is associated with hormone-responsive cancers. We have identified a consensus SUMO modification site in the amino-terminal region of BRCA1/1a/1b proteins and the mutation in this potential SUMO acceptor site (K 109 to R) impaired their ability to bind
Pierre Thouvenot et al.
Journal of cell science, 129(23), 4366-4378 (2016-11-02)
Understanding the effect of an ever-growing number of human variants detected by genome sequencing is a medical challenge. The yeast Saccharomyces cerevisiae model has held attention for its capacity to monitor the functional impact of missense mutations found in human
Geon Kim et al.
Oncology letters, 17(6), 5023-5029 (2019-06-13)
Breast cancer type 1 susceptibility protein (BRCA1) is a tumor suppressor gene that encodes a nuclear phosphoprotein, which is involved in homologous recombination to repair DNA double strand breaks and maintain genome stability. When BRCA1 is mutated or altered, DNA
Drugging DNA repair to target T-ALL cells.
Yashodhara Dasgupta et al.
Leukemia & lymphoma, 59(7), 1746-1749 (2017-11-09)
Nathalie van den Tempel et al.
Cancers, 11(1) (2019-01-18)
The DNA damage response (DDR) is a designation for a number of pathways that protects our DNA from various damaging agents. In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract
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