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Merck
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主要文件

MABT493

Sigma-Aldrich

Anti-IL-34, clone 1D12 Antibody

ascites fluid, clone 1D12, from mouse

别名:

Interleukin-34, IL-34

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

抗体形式

ascites fluid

抗体产品类型

primary antibodies

克隆

1D12, monoclonal

种属反应性

human

技术

flow cytometry: suitable
immunofluorescence: suitable

同位素/亚型

IgG1

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... IL34(146433)

一般描述

Intereukin 34, also known as IL-34 or IL34 is a cytokine that promotes the differentiation and viability of moncytes and macrophages. IL-34 stimulate the phosphorylation of MAPL1/ERK2/ERK2 and MAPK3/ERK1. IL-34 is a ligand for colony-stimulating factor CSF1R. IL-34 is predominantly expressed in spleen, and also detected in a range of other tissues including heart, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.

免疫原

Purified recombinant fragment of human IL-34 expressed in E. Coli

应用

Anti-IL-34, clone 1D12 Antibody is an antibody against IL-34 for use in flow cytometry & immunofluorescence.
Immunofluorescence Analysis: A 1:200-1,000 dilution from a representative lot detected IL-34 in U251 cells.
Research Category
Cell Structure
Research Sub Category
Cytoskeleton

质量

Flow Cytometry Analysis: A 1:200-400 dilution from a representative lot detected IL-34 in K562 cells.

目标描述

27 kDa calculated

外形

Unpurified
Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.

储存及稳定性

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

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Previously, we identified a therapy-resistant role of IL-34 in an immune checkpoint blockade in murine models. To investigate whether a similar mechanism is applicable in human tumors as well, we used this protocol for the selection of IL-34-neutralizing antibody and

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