MAB4148
Anti-MRP2 Antibody, clone M2 I-4
culture supernatant, clone M2 I-4, Chemicon®
别名:
cMOAT
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
M2 I-4, monoclonal
Species reactivity:
human
Application:
ICC, IHC, WB
Citations:
9
biological source
mouse
Quality Level
antibody form
culture supernatant
antibody product type
primary antibodies
clone
M2 I-4, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
Gene Information
human ... ABCC2(1244)
Immunogen
Fusion protein of MRP2 containing aa 215-310 of the protein.
Application
This Anti-MRP2 Antibody, clone M2 I-4 is validated for use in WB, IC, IH for the detection of MRP2.
Western blotting: 1:20 - 1:50 with anti-mouse HRP
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
This antibody reacts with an internal epitope of MRP2, a 190-200 kDa transmembrane protein previously known as the canalicular multi-organic anion transporter (cMOAT). MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. This antibody does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
M Kummu et al.
Placenta, 33(10), 859-865 (2012-08-16)
Heavy metals such as cadmium, lead and methylmercury are known to be neurotoxic to developing fetus. ABCG2 which is an efflux transporter located in the maternal facing membranes of human placenta protects fetus from xenobiotics by transferring compounds from syncytiotrophoblast
Tobacco carcinogen NNK transporter MRP2 regulates CFTR function in lung epithelia: implications for lung cancer.
Chunying Li,John D Schuetz,Anjaparavanda P Naren
Cancer letters null
Päivi Myllynen et al.
Toxicology and applied pharmacology, 232(2), 210-217 (2008-08-06)
We have studied the role of ATP binding cassette (ABC) transporters in fetal exposure to carcinogens using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) a known substrate for ABC transporters as a model compound. In perfusion of human term placenta, transfer of (14)C-PhIP (2 microM)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB4148 | 04053252615078 |