MAB341
抗GABA A受体β2，3链抗体，克隆BD17
clone BD17, Chemicon®, from mouse
别名:
GABA(A) receptor subunit beta-2, gamma-aminobutyric acid (GABA) A receptor, beta 2, gamma-aminobutyric acid A receptor, beta 2
产品名称
抗GABA A受体β2，3链抗体，克隆BD17, clone BD17, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
BD17, monoclonal
species reactivity
mouse, feline, monkey, bovine
species reactivity (predicted by homology)
rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GABRB2(2561)
Analysis Note
通过蛋白质印迹对小鼠大脑膜裂解物进行评估。
蛋白质印迹：
该抗体的1：500稀释液在10μg小鼠脑膜裂解物上检测到GABA A受体β2，3链。
蛋白质印迹：
该抗体的1：500稀释液在10μg小鼠脑膜裂解物上检测到GABA A受体β2，3链。
Application
使用经验证可用于IH、IP &WB的抗GABA A受体β2、3链抗体（克隆BD17）检测GABA A受体β2。
免疫组化：
一个浓度为10-20 μg/mL的先前批次产品已被用于IH中。
免疫沉淀：
一个先前批次该抗体已被用于IP中。
蛋白质印迹：
5-20 µg/mL。识别对应于GABAA受体β链的55 kDa条带。
最佳工作稀释度必须由最终用户确定。
一个浓度为10-20 μg/mL的先前批次产品已被用于IH中。
免疫沉淀：
一个先前批次该抗体已被用于IP中。
蛋白质印迹：
5-20 µg/mL。识别对应于GABAA受体β链的55 kDa条带。
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
与GABAA受体的β-链反应。
General description
γ-氨基丁酸A型（GABAA）受体是神经递质配体门控离子通道的成员，该通道介导神经元抑制结合GABA。GABA对GABAA受体的作用受到一系列重要治疗药物的调节，包括巴比妥类，麻醉药和苯二氮卓类药物。
55kda
Immunogen
来自牛皮质的纯化GABA/苯二氮受体
表位：GABAA受体β2&β3亚基的胞外域
Other Notes
替代品：AB5952
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1液体，溶于含有10 mM磷酸钾缓冲液pH值7.4和150 mM NaCl的缓冲液中
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Daniel C Adusei et al.
Neuropharmacology, 59(3), 167-171 (2010-05-18)
Fragile X syndrome is the most common heritable form of mental retardation. It is caused by silencing of the Fmr1 gene and the absence of the encoded protein. The purpose of this study was to examine global protein expression levels
Human ?1?3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.
Dostalova, Z; Zhou, X; Liu, A; Zhang, X; Zhang, Y; Desai, R; Forman, SA; Miller, KW
Protein Science null
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.
Braun, M; Ramracheya, R; Bengtsson, M; Clark, A; Walker, JN; Johnson, PR; Rorsman, P
Diabetes null
Pengju Ma et al.
International journal of clinical and experimental medicine, 8(8), 14296-14302 (2015-11-10)
This study aimed to investigate GABA effects on blood pressure and blood dynamics of anesthetic rats by observing spontaneously hypertensive rats under both anesthesia and waking state. 72 male waking Wistar-Kyokos (WKY) rats and 72 male anesthetized spontaneously hypertensive (SHR)
Mirko Feldmann et al.
Cerebral cortex (New York, N.Y. : 1991), 29(2), 892-905 (2018-12-12)
Although by adulthood cortical structures and their capacity for processing sensory information have become established and stabilized, under conditions of cortical injury, or sensory deprivation, rapid reorganization occurs. Little is known as to the impact of this kind of adaptation
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