产品名称
抗谷氨酰胺合成酶抗体，克隆GS-6, clone GS-6, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
clone
GS-6, monoclonal
species reactivity
human, rat, mouse, sheep
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GLUL(2752)
相关类别
Analysis Note
对照
大鼠脑组织，大鼠脑细胞质蛋白提取物
大鼠脑组织，大鼠脑细胞质蛋白提取物
Application
使用该抗谷氨酰胺合成酶抗体克隆GS-6检测谷氨酰胺合成酶，经验证可用于ELISA、IH、IH（P）&WB，产品引用超过45次。
研究子类别
神经丝&神经元代谢
神经丝&神经元代谢
研究类别
神经科学
神经科学
蛋白质印迹：1：1,000-1：5,000
大鼠脑的免疫组化
ELISA
最佳工作稀释度必须由最终用户确定。
大鼠脑的免疫组化
ELISA
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
在绵羊脑和大鼠脑的蛋白质印迹上与单条带强烈反应。谷氨酰胺合成酶是一种催化谷氨酸胺化形成谷氨酰胺的酶，在哺乳动物中被发现为八个相同的45 kDa亚基的八聚体。谷氨酰胺合成酶活性已被证明是星形胶质细胞的有用标志物，并且是视网膜中的重要分化特征。谷氨酰胺合成酶也被认为是神经递质谷氨酸再循环中的关键酶。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
45kda
谷氨酰胺合成酶催化氨和谷氨酸转化为谷氨酰胺。星形胶质细胞内，其以相同的45 kDa亚基构成的八聚体形式存在。谷氨酰胺合成酶的功能是脑氨的解毒治疗。在神经递质谷氨酸的代谢调节中也有重要作用。由于谷氨酰胺合成酶在细胞代谢中具有多种功能和重要性，因此催化活性和合成均受到高度调节。谷氨酰胺合成酶的活性受腺苷酰化作用的控制。其活性在受阿尔茨海默氏′病影响的大脑的大脑皮层中降低，特别是在老年斑附近。在葡萄糖剥夺的条件下，它也会降低。在体内缺血或培养物缺氧期间，谷氨酰胺合成酶的表达水平增加。
Immunogen
从羊脑中纯化的谷氨酰胺合成酶。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的免疫球蛋白。含有50%甘油、BSA和0.09%叠氮化钠的缓冲液中的液体。
纯化的蛋白 A
Preparation Note
自收到之日起，以未稀释的分装试样可于-20ºC下稳定保存1年。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Acoustic overstimulation is one of the major causes of hearing loss. Glutamate is the most likely candidate neurotransmitter for afferent synapses in the peripheral auditory system, so it was proposed that glutamate excitotoxicity may be involved in noise trauma. However
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