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生物来源
rat
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
A5, monoclonal
种属反应性
mouse, human
制造商/商品名称
Chemicon®
技术
immunohistochemistry: suitable (paraffin)
同位素/亚型
IgG2aκ
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... LAMC1(3915)
一般描述
层粘连蛋白是细胞外基质糖蛋白的一个家族，是基底膜的主要非胶原蛋白成分。它们与多种生物学过程有关，包括细胞粘附，分化，迁移，信号传导，神经突向生长和转移。胚胎发生、器官发生、创伤后愈合和癌症中都观察到此层粘连蛋白表达变化。发现层粘连蛋白具有促进神经突再生的能力，从而激发了层粘连蛋白。层粘连蛋白由3条不同的链组成：层粘连蛋白α，β和γ（以前分别为A，B1和B2）。以前认为是β链的γ1链包含类似于β链的结构域，但是，缺少分隔结构域I和II的短α区。通过同源重组使γ1链基因的两个等位基因失活的转基因小鼠的胚胎缺乏基底膜，表明层粘连蛋白γ1链对于层粘连蛋白异源三聚体组装是必需的。
免疫原
从小鼠EHS肿瘤制备基底膜蛋白。
应用
使用经验证可用于IH（P）的抗层粘连蛋白γ1抗体（克隆A5）检测层粘连蛋白γ1。
研究子类别
ECM蛋白
粘附（CAMs）
ECM蛋白
粘附（CAMs）
目标描述
177kda
外形
形式：纯化
纯化的大鼠免疫球蛋白溶于含有0.1 M Tris-甘氨酸（pH7.4）150mM NaCl和0.05%NaN3的缓冲液中。
分析说明
对照
结肠管状癌与纤维神经瘤
结肠管状癌与纤维神经瘤
其他说明
浓度：请参考批次特异性浓缩物的分析证书。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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