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MILLIPLEX® 人淀粉样蛋白β和Tau磁珠板 - 多重分析

Configurable Human Amyloid Beta and Tau 4-Plex Panel, allows quantitative multiplex detection of multiple analytes simultaneously

别名:

Human Neuroscience Protein Multiplex Assay, Luminex® Human Neuroscience Panel, Millipore Human Neuroscience Immunoassay

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关于此项目

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
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产品名称

MILLIPLEX® 人淀粉样蛋白β和Tau磁珠板 - 多重分析, Configurable Human Amyloid Beta and Tau 4-Plex Panel, allows quantitative multiplex detection of multiple analytes simultaneously

Quality Level

species reactivity

human

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 109%
(Spike recovery for Aβ1-42)

accuracy: 91%
(Spike recovery for pTau181)

accuracy: 98%
(Spike recovery for tTau)

sensitivity: 1.5 pg/mL
(pTau181; MinDC+2SD)

sensitivity: 10.2 pg/mL
(Aβ1-40; MinDC+2SD)

sensitivity: 14.2 pg/mL
(tTau; MinDC+2SD)

sensitivity: 2.5 pg/mL
(Aβ1-42; MinDC+2SD)

standard curve range: 0.7-500 pg/mL
(pTau181)

standard curve range: 11-8000 pg/mL
(tTau)

standard curve range: 2-2000 pg/mL
(Aβ1-42)

standard curve range: 21-15000 pg/mL
(Aβ1-40)

inter-assay cv: <15%
intra-assay cv: <10%

technique(s)

multiplexing: suitable

input

cerebrospinal fluid(s) (CSF)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 4 analytes in human cerebrospinal fluid (CSF).Analytes included: Amyloid beta 1-40 (Aβ40), Amyloid beta 1-42 (Aβ42), Total Tau proteins (tTau), and Phosphorylated Tau Thr181 (pTau181).Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Harness Mutliplexing Efficiency: Simultaneously measure both Aβ40 and Aβ42 in a single assay, accelerating your neurodegenerative disease research while maximizing laboratory throughput.Built-in Reliability: Every kit undergoes rigorous validation to deliver unwavering consistency across batches, giving you the confidence to pursue breakthrough discoveries without questioning your data integrity.Biologically Relevant Results: Our specially formulated serum matrix replicates physiological conditions, ensuring your findings accurately measure the analytes of interest.Complete Research Solution: Eliminate procurement headaches with our comprehensive kit containing all essential components, allowing you to focus on scientific discovery rather than logistical challenges.Accelerate Scientific Impact: Transform precise biomarker measurements into actionable insights that drive forward our understanding of Alzheimer′s disease and related amyloidopathies.

General description

Alzheimer′s disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting approximately 36 million people worldwide. The disease is characterized by two key features: extracellular amyloid β (Aβ) plaques formed from peptides like Aβ1-40 and Aβ1-42, and intracellular neurofibrillary tangles composed of hyperphosphorylated Tau protein. These biomarkers—reduced soluble Aβ1-42, increased total Tau, and phosphorylated Tau in cerebrospinal fluid—serve as critical indicators of the pathological processes underlying neurodegenerative conditions.

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

法规信息

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Francheska Delgado-Peraza et al.
Cells, 10(5) (2021-05-01)
Circulating neuronal extracellular vesicles (NEVs) of Alzheimer's disease (AD) patients show high Tau and β-amyloid (Aβ) levels, whereas their astrocytic EVs (AEVs) contain high complement levels. To validate EV proteins as AD biomarkers, we immunocaptured NEVs and AEVs from plasma
Wencheng Yin et al.
Frontiers in neuroscience, 14, 602642-602642 (2021-01-05)
Alzheimer's disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and neurological decline are still unclear. Here we combine genome-wide transcriptional
Mohamed Raâfet Ben Khedher et al.
Alzheimer's & dementia (New York, N. Y.), 7(1), e12124-e12124 (2021-02-05)
In brain, extracellular vesicles (EVs) play an essential role in the neuron-glia interface and ensure the crosstalk between the brain and the periphery. Some studies now link the pathway dysfunction of the EVs to apolipoprotein E gene variant (APOE ε4)
Jessica L Hoffman et al.
International review of neurobiology, 148, 169-230 (2019-11-18)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the most common cause of dementia in the United States. Although the link between alcohol use and AD has been studied, preclinical research has potential to elucidate neurobiological mechanisms that
Barbara Miziak et al.
Pharmaceuticals (Basel, Switzerland), 14(5) (2021-06-03)
Alzheimer's disease (AD; progressive neurodegenerative disorder) is associated with cognitive and functional impairment with accompanying neuropsychiatric symptoms. The available pharmacological treatment is of a symptomatic nature and, as such, it does not modify the cause of AD. The currently used

实验方案

A stem cell culture protocol to generate 3D NSC models of Alzheimer’s disease using ReNcell human neural stem cell lines.

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