MILLIPLEX^® Human Cardiovascular Disease Panel

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Cardiovascular disease, particularly atherosclerotic vascular disease, is a leading cause of global mortality, accounting for 30% of all global deaths (WHO, 2010). Inflammatory mechanisms play a vital role in the initiation, maintenance, and progression of vascular disease with a strong correlation between inflammatory markers and prognosis in acute and chronic coronary artery disease. Numerous studies have demonstrated an association of obesity and diabetes with cardiovascular risk factors.

MILLIPLEX^® Human Cardiovascular Disease (CVD) Panel 2 is a 10-plex kit to be used for the simultaneous quantification of any or all of the following analytes in human serum, plasma and tissue/cell lysate and culture supernatant samples: Adamts13, D-dimer, GDF-15, Myoglobin, sICAM-1, MPO, P-selectin, Lipocalin-2/NGAL, sVCAM-1 and SAA. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex^® xMAP^® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cardiovascular

Cardiovascular disease is closely linked to inflammation, endothelial dysfunction, oxidative stress, and coagulation abnormalities. This set of biomarkers—ADAMTS13, D-dimer S, GDF15, sICAM-1, Myeloperoxidase (MPO), Myoglobin, NGAL/Lipocalin-2, sP-Selectin, Serum Amyloid A, and sVCAM-1—captures key indicators of vascular injury, immune activation, and thrombotic risk. These analytes are widely studied in the context of atherosclerosis, acute coronary syndromes, and systemic inflammation, making them highly relevant for translational and clinical cardiovascular research.

Sensitivity: See kit protocol for individual analytes sensitive’s.

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 10 analytes in human serum, plasma, or cell culture supernatants.Analytes included: ADAMTS13, D-dimer S, GDF15, sICAM-1, Myeloperoxidase (MPO), Myoglobin, NGAL/Lipocalin-2, sP-Selectin, Serum Amyloid A, sVCAM-1Note: D-Dimer cannot be measured in plasma samples.Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Features:

• Targets biomarkers involved in vascular inflammation, endothelial activation, and coagulation
• Includes 10 analytes relevant to cardiovascular risk, oxidative stress, and immune response
• Multiplex format enables simultaneous detection from minimal sample volume
• Compatible with human serum and plasma samples
• Designed for research in atherosclerosis, thrombosis, acute coronary syndromes, and systemic inflammation

Benefits:

• Provides a comprehensive profile of cardiovascular and inflammatory biomarkers
• Supports investigation of vascular injury, immune activation, and thrombotic mechanisms
• Facilitates evaluation of therapeutic interventions and biomarker-based risk assessment
• Enables high-throughput analysis with reduced sample and reagent use
• Delivers reproducible, sensitive results for translational and clinical research