FCMAB418PE-I
Milli-Mark® Anti-CAR-PE Antibody, clone RmcB
clone RmcB, Milli-Mark®, from mouse
别名:
46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3 binding protein, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, coxsackie virus B receptor, coxsackie virus and adenovirus receptor
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
PE
Clone:
RmcB, monoclonal
Application:
flow cytometry
Species reactivity:
human
Citations:
2
Technique(s):
flow cytometry: suitable
Uniprot accession no.:
产品名称
Milli-Mark® Anti-CAR-PE Antibody, clone RmcB, clone RmcB, Milli-Mark®, from mouse
biological source
mouse
conjugate
PE
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RmcB, monoclonal
species reactivity
human
manufacturer/tradename
Milli-Mark®
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CXADR(1525)
Analysis Note
Control
HT-29 cells
HT-29 cells
Evaluated by flow cytometry using HT-29 cells.
Application
Detect CAR using this Milli-Mark Anti-CAR-PE Antibody, clone RmcB validated for use in FC.
Research Category
Cell Structure
Cell Structure
Research Sub Category
ECM Proteins
ECM Proteins
Biochem/physiol Actions
Antibody recognizes CAR.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
The coxsackievirus and adenovirus receptor (CAR) mediates cell attachment and infection by coxsackie B viruses and by a number of adenoviruses. CAR also mediates homotypic intercellular interactions. In polarized epithelial cells, CAR is closely associated with the tight junction, where it contributes to the barrier to paracellular flow of solutes and macromolecules. CAR′s biological roles are not well defined, but emerging evidence suggests that it may function during embryonic development and in regulating cell proliferation.
40 kDa Calculated. Uniprot indicates multiple isoforms ranging from 9 to 40 kDa
Immunogen
Native human coxsackie virus-adenovirus receptor protein
Other Notes
Unconjugated version Cat. No. 05-644 is known to react with Mouse and Rat.
Physical form
Protein G Purified
Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Preparation Note
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Legal Information
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Michael Klichinsky et al.
Nature biotechnology, 38(8), 947-953 (2020-05-04)
Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic malignancies, but its application to solid tumors has been challenging1-4. Given the unique effector functions of macrophages and their capacity to penetrate tumors5, we genetically engineered human macrophages
Hongkang Xi et al.
The Journal of experimental medicine, 213(2), 189-207 (2016-01-13)
Age-related macular degeneration (AMD), a leading cause of vision impairment in the ageing population, is characterized by irreversible loss of retinal pigment epithelial (RPE) cells and photoreceptors and can be associated with choroidal neovascularization. Mononuclear phagocytes are often present in
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