CP18
抗胶原II型（Ab-1）小鼠mAb（II-4C11）
liquid, clone II-4C11, Calbiochem®
别名:
胶原蛋白II型抗体
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Clone:
II-4C11, monoclonal
Species reactivity:
rat, human, bovine, rabbit
Application:
Citations:
42
产品名称
抗胶原II型（Ab-1）小鼠mAb（II-4C11）, liquid, clone II-4C11, Calbiochem®
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
II-4C11, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
rat, human, bovine, rabbit
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
dilution
(Frozen Sections (1-10 µg/mL)
Immunoblotting (1-5 µg/mL,
Paraffin Sections (1-10 µg/mL, )
isotype
IgG1
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL2A1(1280)
Application
冷冻切片（1-10 µg/ml）
免疫印迹（1-5 µg/ml，请参阅应用参考）
石蜡切片（1-10 µg/ml，请参阅应用参考）
免疫印迹（1-5 µg/ml，请参阅应用参考）
石蜡切片（1-10 µg/ml，请参阅应用参考）
Disclaimer
毒性：标准处理（A）
General description
可识别约130 kDa的II型胶原蛋白。可能与其他胶原发生反应。当以高浓度使用时，也可以检测到对应于聚集体的更高条带。
经验证，该抗II型胶原（Ab-1）小鼠mAb（II-4C11）可用于冰冻切片检测II型胶原（Ab-1）。
通过用指定的免疫原免疫BALB/c小鼠并将脾细胞与P3-X-63-Ag8-LUI小鼠骨髓瘤融合而产生的纯化的小鼠单克隆抗体。可识别约130 kDa的II型胶原蛋白。
Immunogen
人
纯化的II型胶原
Legal Information
由Daiichi Fine Chemical Co.，Ltd.生产，未在日本销售。
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Kumagai, J. et al. 1994 J. Anat.185, 278.
Kivrikko, K,I.1993 Ann.Med.25, 113.
Sandell, L.J., et al. 1991 J. Cell.Biol.114, 1307.
Ryan, M.C., and Sandell, L.J.1990 J. Biol. Chem.265, 10334.
Mayne, R., and Burgeson, R.E.1987 Structure and Function of Collagen Types,Academic Press, Orlando, FL
Kivrikko, K,I.1993 Ann.Med.25, 113.
Sandell, L.J., et al. 1991 J. Cell.Biol.114, 1307.
Ryan, M.C., and Sandell, L.J.1990 J. Biol. Chem.265, 10334.
Mayne, R., and Burgeson, R.E.1987 Structure and Function of Collagen Types,Academic Press, Orlando, FL
可能与其他胶原发生反应。当以高浓度使用时，也可以检测到对应于聚集体的更高条带。该抗体也可以在高于1 µg/mL的浓度下与其他类型的胶原反应。在免疫印迹中，获得了约130 kDa的主要条带。在单个系统中，应对抗体进行滴定以获得最佳结果。
Packaging
请参考特定浓度批号的标签。
Physical form
溶于100 mM磷酸钠缓冲液，0.1% BSA（pH 7.0）。
Preparation Note
初次融化后，等分并冷冻（-20°C）。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Han-Jun Kim et al.
Oxidative medicine and cellular longevity, 2020, 5915481-5915481 (2020-10-09)
Intervertebral disc degeneration (IVDD) is a common cause of lower back pain. Programmed cell death (PCD) including apoptosis and autophagy is known to play key mechanistic roles in the development of IVDD. We hypothesized that the nucleus pulposus cells that
Silencing of Wnt5a prevents interleukin-1β-induced collagen type II degradation in rat chondrocytes.
Shiping Shi et al.
Experimental and therapeutic medicine, 12(5), 3161-3166 (2016-11-25)
Osteoarthritis (OA) is a joint disease, and few treatments to date have been able to delay OA progression. The degradation of collagen type II (COL2) in the cartilage matrix is an important initiating factor for OA progression; the upregulation of
En-Rung Chiang et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37(6), 1440-1450 (2019-05-08)
Intervertebral discs (IVDs) are important biomechanical components of the spine. Once degenerated, mesenchymal stem cell (MSC)-based therapies may aid in the repair of these discs. Although hypoxic preconditioning enhances the chondrogenic potential of MSCs, it is unknown whether bone marrow
María Satué et al.
Scientific reports, 9(1), 10153-10153 (2019-07-14)
Intra-articular (IA) injection of mesenchymal stem cells (MSCs) promotes articular cartilage repair. However, cell fate and action after transplantation remain unclear. This study aimed at evaluating the biodistribution and efficacy of MSCs after IA injection. We used an immunocompetent, dual
En-Rung Chiang et al.
PloS one, 11(2), e0149835-e0149835 (2016-02-26)
Mesenchymal stem cell (MSC)-based therapies may aid in the repair of articular cartilage defects. The purpose of this study was to investigate the effects of intraarticular injection of allogeneic MSCs in an in vivo anterior cruciate ligament transection (ACLT) model
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