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Merck
CN
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主要文件

安全信息

CH2900011

SAFC

亚叶酸 钙盐

Ph. Eur., USP

制药生产

别名:

叶醛酸钙

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About This Item

经验公式（希尔记法）:
C20H21CaN7O7
CAS号:
1492-18-8
分子量:
511.50
MDL编号:
MFCD00006704
UNSPSC代码:
41116107

生物来源

synthetic

质量水平

600

等级

GMO free
GMP
Halal
Kosher

Agency

Ph. Eur.
USP

表单

powder

应用

pharmaceutical
solid formulation

储存温度

2-8°C

SMILES字符串

[Ca+2].[nH]1c2c([c](nc1N)=O)N(C(CN2)CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])C=O

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChI key

KVUAALJSMIVURS-ZEDZUCNESA-L

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一般描述

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Calcium Folinate Hydrate crystalline has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

包装

Customized packaging possible

法律信息

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Arcofolin® Methylfolate as a superior alternative to Folic Acid has uniquely become available for nutritional supplementation and fortification.

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