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Merck
CN
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主要文件

CBL1366

Sigma-Aldrich

Anti-CD140a Antibody, clone APA5

clone APA5, Chemicon®, from rat

别名:

PDGF Receptor alpha

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rat

质量水平

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

APA5, monoclonal

种属反应性

mouse

制造商/商品名称

Chemicon®

技术

ELISA: suitable
flow cytometry: suitable
immunohistochemistry: suitable
western blot: suitable

同位素/亚型

IgG2aκ

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... PDGFRA(5156)

特异性

Specifically recognizes mouse CD140a, the alpha chain of PDGF receptor. A receptor tyrosine kinase, PDGFRa forms dimers on the surface upon ligand binding and phosphorylates substrates. CD140a is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues.

应用

Detect CD140a using this Anti-CD140a Antibody, clone APA5 validated for use in ELISA, FC, WB, IH.
Flow Cytometry: ≤ 1 μg per 10E6 cells

ELISA

Immunohistochemistry: 10μg/mL

Blocking of Ligand Binding

Western Blotting

Optimal working dilutions must be determined by the end user.
Research Category
Signaling
Research Sub Category
Growth Factors & Receptors

外形

Format: Purified
Purified immunoglobulin in PBS, 150 mM NaCl, pH 7.2, containing 0.09% sodium azide.

储存及稳定性

Maintain at 2-8°C for up to 12 months from date of receipt.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 2

闪点(°F)

does not flash

闪点(°C)

does not flash


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Maria Anesti et al.
Cells, 11(11) (2022-06-11)
Two main stem cell pools exist in the postnatal mammalian brain that, although they share some "stemness" properties, also exhibit significant differences. Multipotent neural stem cells survive within specialized microenvironments, called niches, and they are vulnerable to ageing. Oligodendroglial lineage-restricted
Magali Macchi et al.
eLife, 9 (2020-06-10)
Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan
Bilal El Waly et al.
iScience, 25(10), 105102-105102 (2022-10-04)
After demyelinating insult, the neuronal progenitors of the adult mouse sub-ventricular zone (SVZ) called neuroblasts convert into oligodendrocytes that participate to the remyelination process. We use this rare example of spontaneous fate conversion to identify the molecular mechanisms governing these
Haley E Titus et al.
Glia, 70(10), 1950-1970 (2022-07-10)
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by inflammation, demyelination, and neurodegeneration. The ideal MS therapy would both specifically inhibit the underlying autoimmune response and promote repair/regeneration of myelin as well as maintenance of axonal
Lida Zoupi et al.
Glia, 66(3), 576-591 (2017-11-23)
The oligodendrocyte maturation process and the transition from the pre-myelinating to the myelinating state are extremely important during development and in pathology. In the present study, we have investigated the role of the cell adhesion molecule CNTN2/TAG-1 on oligodendrocyte proliferation

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