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一般描述
β 淀粉样蛋白 1-42是整合膜结合淀粉样前体蛋白的衍生物。它是阿尔茨海默′病肽的最重要形式。
应用
β 淀粉样蛋白 1-42, aβ, 超纯, HFIP, 重组人已用于：
- 通过膜片钳（patch-clamp）技术研究其对人星形细胞瘤细胞中线粒体BKCa（mitoBKCa）活性的影响
- 研究其对小鼠成神经细胞瘤细胞中营养不良性神经突（DN）形成蛋白的蛋白质水平变化的影响
- 诱发实验研究用大鼠模型的阿尔茨海默病
生化/生理作用
β 淀粉样蛋白1-42 导致神经毒性，并与阿尔茨海默病的发病机制有关。 β 淀粉样蛋白（βA） 可作为许多受体和其它分子的配体，参与组织和血脑屏障中的复杂运输途径（trafficking pathway）。β它和淀粉不溶素一起提高环磷酸腺苷（cAMP）和 Ca2+水平，继而激活多个信号通路介导子，如丝裂原激活蛋白激酶（MAPK）、 蛋白激酶A/B和 cFOS。它也是AD相关神经炎症的主要来源。
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Annika Olsson et al.
Clinical chemistry, 51(2), 336-345 (2004-11-26)
To simultaneously study several biomarkers for Alzheimer disease (AD), we used the xMAP technology to develop and evaluate a multiparametric bead-based assay for quantification of beta-amyloid((1-42)) [Abeta((1-42))], total tau (T-TAU), and hyperphosphorylated tau [P-TAU((181P))] in cerebrospinal fluid (CSF). We compared
Stephanie J Soscia et al.
PloS one, 5(3), e9505-e9505 (2010-03-09)
The amyloid beta-protein (Abeta) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Abeta is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. However, Abeta has been shown to be a
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Avicenna journal of phytomedicine, 9(5), 465-473 (2019-09-14)
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Although a large amount of evidence has revealed that amyloid β (Aβ), especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the pathophysiological processes of Alzheimer's disease, most clinical trials of anti-Aβ antibody therapy have never acquired successful efficacy
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