ABN1009
抗-TRPA1抗体
from rabbit, purified by affinity chromatography
别名:
Transient receptor potential cation channel subfamily A member 1, TRPA1, Ankyrin-like with transmembrane domains protein 1, Transformation-sensitive protein p120
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
rat, mouse, human
Citations:
5
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-TRPA1抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, mouse, human
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TRPA1(8989)
Analysis Note
通过蛋白质印迹对大鼠脑膜组织裂解液进行了评估。
蛋白质印迹分析：0.1 µg/mL该抗体在 10 µg 大鼠脑膜组织裂解液中检测到TRPA1。
蛋白质印迹分析：0.1 µg/mL该抗体在 10 µg 大鼠脑膜组织裂解液中检测到TRPA1。
Application
免疫组化分析：代表性批次的1：50-1,000稀释液在大鼠小脑，大鼠后脑和大鼠胰腺组织中检测到TRPA1。
抗TRPA1抗体是一种针对TRPA1的抗体，用于蛋白质印迹和免疫组化。
General description
瞬时受体电位A1（又称瞬时受体电位锚蛋白1）是疼痛通路初级感觉神经上的兴奋性离子通道。它由人类中的TRPA1/ANKTM1基因编码（大鼠&小鼠中的Trpa1/Anktm1），在与组织损伤，炎症和神经损伤相关的疼痛中起关键作用。据报告，TRPA1在大鼠背根神经节（DRG）神经元中与PAR2共定位并与TRPV1（瞬时受体电位香草酸1）共表达。激动剂诱导的TRPA1电流显示PAR2通过促炎性胰蛋白酶&类胰蛋白酶（PMID 17571167）裂解/激活后增强。据报告，TRPA1激活反过来以钙和PKA依赖性方式导致TRPV1磷酸化和活性增强（PMID 24275229）。
观察值〜130 kDa。某些裂解液可能会出现未表征的条带。
Immunogen
KLH偶联的线性肽，对应于人TRPA1的细胞质域。
Other Notes
浓度：请参考特定批次的数据表。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Frontiers in neurology and neuroscience research null
Tomás S Huerta et al.
Journal of neural engineering, 20(2) (2023-03-16)
Objective.Sensory nerves of the peripheral nervous system (PNS) transmit afferent signals from the body to the brain. These peripheral nerves are composed of distinct subsets of fibers and associated cell bodies, which reside in peripheral ganglia distributed throughout the viscera
Xiangchen Kong et al.
Molecular metabolism, 29, 1-11 (2019-11-02)
Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does so remains unclear. Farnesoid X receptor (FXR), the nuclear receptor of bile acids (BAs), is implicated in
Min Xia et al.
Frontiers in molecular neuroscience, 12, 98-98 (2019-05-07)
Intracerebral hemorrhage (ICH) is a devastating disease that is characterized by high morbidity and high mortality. ICH has an annual incidence of 10-30/100,000 people and accounts for approximately 10%-30% of all types of stroke. ICH mostly occurs at the basal
Daniel G Blackmore et al.
Molecular psychiatry, 26(11), 6975-6991 (2021-05-28)
Advanced physiological aging is associated with impaired cognitive performance and the inability to induce long-term potentiation (LTP), an electrophysiological correlate of memory. Here, we demonstrate in the physiologically aged, senescent mouse brain that scanning ultrasound combined with microbubbles (SUS+MB), by
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