AB5908
抗钾通道HERG抗体，CT
Chemicon®, from rabbit
别名:
Erg1, Kcnh2
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Species reactivity:
human
Citations:
7
Technique(s):
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗钾通道HERG抗体，CT, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNH2(3757)
Immunogen
GST融合蛋白，对应于人erg1（HERG）的氨基酸1106-1159（登录号Q12809）。
表位：C端
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Analysis Note
对照
对照抗原：该抗体免费包含120 μg融合蛋白（35 kD）。可以使用100 μL PBS配制抗原的贮备液。对于阴性对照，将3 μg融合蛋白与1 μg抗体在室温下预培养1小时。对于阳性对照，每个泳道使用20 ng融合蛋白。最佳浓度必须由最终用户确定。
对照抗原：该抗体免费包含120 μg融合蛋白（35 kD）。可以使用100 μL PBS配制抗原的贮备液。对于阴性对照，将3 μg融合蛋白与1 μg抗体在室温下预培养1小时。对于阳性对照，每个泳道使用20 ng融合蛋白。最佳浓度必须由最终用户确定。
Application
抗钾通道HERG抗体，C末端是一种抗钾通道HERG的抗体，用于IC、IP &WB。
研究子类别
离子通道 & 转运体
离子通道 & 转运体
研究类别
神经科学
神经科学
蛋白质印迹：1：200-400，使用ECL对HERG转染的HEK293细胞进行检测。
免疫细胞化学
免疫沉淀
稀释应使用载体蛋白（例如BSA（1-3%））进行
最佳工作稀释度必须由最终用户确定。
免疫细胞化学
免疫沉淀
稀释应使用载体蛋白（例如BSA（1-3%））进行
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
识别HERG（hKv11.1，电压门控K+通道亚家族H成员2，KCNH2，ether-a-go-go相关通道）。该抗体识别HERG1b剪接变体，但不识别剪接变体HERG1-3或HERG-4。免疫原与大鼠erg2（22/54）和大鼠erg3（21/54）具有相似性。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
127kda
Physical form
亲和纯化的免疫球蛋白。 从含有1% BSA和0.025%叠氮化钠作为防腐剂的pH7.4磷酸盐缓冲盐水中进行冻干。用200 μL无菌去离子水复溶。使用前离心抗体制备（10,000 xg，5 min）。
免疫亲和纯化
Preparation Note
在接收之日起，将冻干物料在-20°C下保存长达12个月。复溶后以未稀释等分试样在 -20°C保存长达 6个月。应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jian-Hua Gong et al.
Oncology reports, 23(6), 1747-1756 (2010-04-30)
Potassium channels are essential for the regulation of cell proliferation. As reported, HERG protein is overexpressed in a wide range of human tumors, including colon carcinoma. The aim of this study was to investigate the effects of antibacterial agents sparfloxacin
Samir Saba et al.
Heart rhythm, 5(1), 124-130 (2008-01-09)
Biventricular (BIV) pacing can improve cardiac function in heart failure (HF). This study sought to investigate the mechanisms of benefit of BIV pacing using a rabbit model of myocardial infarction (MI). New Zealand White rabbits were divided into 4 groups
Karen M Hurley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(40), 10253-10269 (2006-10-06)
Type I vestibular hair cells have large K+ currents that, like neuronal M currents, activate negative to resting potential and are modulatable. In rodents, these currents are acquired postnatally. In perforated-patch recordings from rat utricular hair cells, immature hair cells
Alberto Zullo et al.
International journal of molecular sciences, 18(8) (2017-07-28)
Congenital long QT syndrome (LQTS) is associated with high genetic and allelic heterogeneity. In some cases, more than one genetic variant is identified in the same (compound heterozygosity) or different (digenic heterozygosity) genes, and subjects with multiple pathogenic mutations may
Jochen Rose et al.
American journal of physiology. Heart and circulatory physiology, 288(5), H2077-H2087 (2005-01-08)
Action potential (AP) prolongation is a hallmark of failing myocardium. Functional downregulation of K currents is a prominent feature of cells isolated from failing ventricles. The detailed changes in K current expression differ depending on the species, the region of
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