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AB5350

Sigma-Aldrich

Anti-Potassium Channel SK3 Antibody

Chemicon®, from rabbit

别名:

KCa3, Kcnn3, SKCa3

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

affinity purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

human, rat

制造商/商品名称

Chemicon®

技术

western blot: suitable

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... KCNN4(3783)

特异性

Recognizes SK3. The epitope specific for SK3 is not present in any other known proteins. The immunogen sequence is identical in mouse and porcine.

免疫原

Highly purified peptide corresponding to residues 2-21 of human SK3 (Accession Q9UGI6).

应用

Anti-Potassium Channel SK3 Antibody detects level of Potassium Channel SK3 & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
Western blotting: 1.0-1.5 μg/mL (1:200-1:300)

Dilutions should be made using a carrier protein such as BSA (1-3%).

Optimal working dilutions must be determined by the end user.

外形

Affinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA, 5% sucrose and 0.025% sodium azide. Reconstitute with 200 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min).

储存及稳定性

Maintain lyophilized material at -20°C for up to 6 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

分析说明

Control
CONTROL ANTIGEN: Included free of charge with the antibody is 20 μg of control antigen (lyophilized powder). Reconstitute with 100 μL of sterile distilled water. For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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危险声明

预防措施声明

危险分类

Aquatic Chronic 3

WGK

WGK 3


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Adam S Deardorff et al.
The Journal of physiology, 599(5), 1391-1420 (2021-01-16)
The spatial and temporal balance of spinal α-motoneuron (αMN) intrinsic membrane conductances underlies the neural output of the final common pathway for motor commands. Although the complete set and precise localization of αMN K+ channels and their respective outward conductances
S Shekar Dukkipati et al.
The Journal of physiology, 596(9), 1723-1745 (2018-03-05)
Motoneuron soma size is a largely plastic property that is altered during amyotrophic lateral sclerosis (ALS) progression. We report evidence of systematic spinal motoneuron soma size plasticity in mutant SOD1-G93A mice at various disease stages and across sexes, spinal regions
Histone deacetylase inhibitors (HDACi) increase expression of KCa2.3 (SK3) in primary microvascular endothelial cells.
Kolski-Andreaco, et al.
American Journal of Physiology. Cell Physiology, 322, C338-C353 (2023)

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