产品名称
抗钠通道抗体，电压门控，脑I型, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SCN1A(6323)
Application
将要接收全长蛋白的全部程序应在4C下进行，并应使用以下蛋白酶抑制剂混合物：胃蛋白酶抑制剂A（1 μg/mL），亮抑蛋白酶肽（1 μg/mL），抑肽酶（1 μg/mL），Pefabloc SC（0.2 mM），苯甲脒（0.1 mg/mL）和钙蛋白酶抑制剂I和II（各8 μg/mL）。
蛋白质印迹：在大鼠脑膜上使用ECL为L1：200。
大鼠脑固定冰冻切片和小鼠心脏组织上的免疫组化。
应使用载体蛋白（例如BSA（1-3%））进行稀释。
最佳工作稀释度必须由最终用户确定。
蛋白质印迹：在大鼠脑膜上使用ECL为L1：200。
大鼠脑固定冰冻切片和小鼠心脏组织上的免疫组化。
应使用载体蛋白（例如BSA（1-3%））进行稀释。
最佳工作稀释度必须由最终用户确定。
该抗钠通道抗体，电压门控，脑I型经验证可用于IH，WB检测钠通道。
Biochem/physiol Actions
识别VGSC的I型α亚基。不与迄今为止检测的任何其他钠通道抗原发生交叉反应。
物种反应性： 由于序列同源性，预计该抗体也与人反应。其他物种尚未经过测试。
物种反应性： 由于序列同源性，预计该抗体也与人反应。其他物种尚未经过测试。
Immunogen
来自大鼠I型电压门控钠通道（VGSC）的α亚基465-481的纯化肽（登录号P04774）。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
11 - Combustible Solids
wgk
WGK 3
Cécile Brocard et al.
Nature medicine, 22(4), 404-411 (2016-03-15)
Upregulation of the persistent sodium current (I(NaP)) in motoneurons contributes to the development of spasticity after spinal cord injury (SCI). We investigated the mechanisms that regulate I(NaP) and observed elevated expression of voltage-gated sodium (Nav) 1.6 channels in spinal lumbar
Yishan Sun et al.
eLife, 5 (2016-07-28)
Dravet Syndrome is an intractable form of childhood epilepsy associated with deleterious mutations in SCN1A, the gene encoding neuronal sodium channel Nav1.1. Earlier studies using human induced pluripotent stem cells (iPSCs) have produced mixed results regarding the importance of Nav1.1
Elena Spoleti et al.
Molecular psychiatry, 29(5), 1265-1280 (2024-01-17)
Early and progressive dysfunctions of the dopaminergic system from the Ventral Tegmental Area (VTA) have been described in Alzheimer's Disease (AD). During the long pre-symptomatic phase, alterations in the function of Parvalbumin interneurons (PV-INs) are also observed, resulting in cortical
Tun Li et al.
PLoS biology, 12(9), e1001944-e1001944 (2014-09-10)
Action potential (AP) generation in inhibitory interneurons is critical for cortical excitation-inhibition balance and information processing. However, it remains unclear what determines AP initiation in different interneurons. We focused on two predominant interneuron types in neocortex: parvalbumin (PV)- and somatostatin
Alex C Bender et al.
PloS one, 11(3), e0151538-e0151538 (2016-03-16)
Brain oscillations play a critical role in information processing and may, therefore, be essential to uncovering the mechanisms of cognitive impairment in neurological disease. In Dravet syndrome (DS), a mutation in SCN1A, coding for the voltage-gated sodium channel Nav1.1, is
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