产品名称
Anti-Na+/H+ Exchanger-1 Antibody, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, rat, bovine, mouse, pig
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC9A1(6548)
Application
Detect Na+/H+ Exchanger-1 using this Anti-Na+/H+ Exchanger-1 Antibody validated for use in ELISA & WB.
Western blot: 1-10 μg/mL using Chemiluminescence technique.
ELISA: 1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by end user.
ELISA: 1:100,000 using 50-100 ng control peptide per well.
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Recognizes Na+/H+ Exchanger 1 (NHE1). The immunogen peptide shows no significant homology with other NHE isoforms (NHE2-5).
General description
91 kDa
Immunogen
A 22 aa peptide within the cytoplasmic, C-terminal domain of rat NHE1, coupled to KLH.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity Purified immunoglobulin. Liquid in PBS and 0.1% BSA .
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Bryan J Feger et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(10), R1182-R1189 (2013-09-21)
The myocardial Na(+)/H(+) exchanger-1 (NHE1) plays a major role in regulation of intracellular pH, and its upregulation has been implicated in increased ischemia-reperfusion injury and other pathologies. Hydrogen peroxide (H2O2) increases NHE1 activity acutely via ERK1/2 signaling. Chronic strenuous exercise
Chao Huang et al.
Journal of neuroscience research, 93(8), 1192-1202 (2015-02-19)
Inducible nitric oxide synthase (iNOS) critically contributes to inflammation and host defense. The inhibition of heat shock protein 70 (Hsp70) prevents iNOS induction in lipopolysaccharide (LPS)-stimulated macrophages. However, the role and mechanism of endogenous Hsp70 in iNOS induction in microglia
Hilmi Burak Kandilci et al.
Frontiers in cardiovascular medicine, 7, 617038-617038 (2021-02-16)
Fully-activated Na+/H+ exchanger-1 (NHE1) generates the cardiomyocyte's largest trans-membrane extrusion of H+ ions for an equimolar influx of Na+ ions. This has the desirable effect of clearing excess intracellular acidity, but comes at a large energetic premium because the exchanged
Zhongyan Lu et al.
Journal of dairy science, 99(1), 733-745 (2015-11-09)
Low sodium content in feed and large amounts of salivary sodium secretion are essential requirements to efficient sodium reabsorption in the dairy cow. It is already known that Na(+)/H(+) exchange (NHE) of the ruminal epithelium plays a key role in
Danny Christiansen et al.
Acta physiologica (Oxford, England), 231(3), e13580-e13580 (2020-11-23)
To assess how blood-flow-restricted (BFR) interval-training affects the capacity of the leg muscles for pH regulation during dynamic exercise in physically trained men. Ten men (age: 25 ± 4y; V˙O2max : 50 ± 5 mL∙kg-1 ∙min-1 ) completed a 6-wk interval-cycling intervention (INT) with one
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