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Merck
CN

AB2272

抗ZO -1抗体

from rabbit, purified by affinity chromatography

别名:

tight junction protein 1, zonula occludens 1 protein, Zona occludens protein 1, Zonula occludens protein 1, zona occludens 1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

抗ZO -1抗体, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

mouse (based on 100% sequence homology)

packaging

antibody small pack of 25 μg

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

NP_003248

UniProt accession no.

Q07157

shipped in

ambient
wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TJP1(7082)

相关类别

Analysis Note

对照
HepG2 细胞裂解液
通过蛋白质印迹对HepG2细胞裂解液进行了评估。

蛋白质印迹分析：0.1 µg/ml该抗体可在10 µg的HepG2细胞裂解液中检测到ZO-1。

Application

使用经过验证可用于WB、IH（P）的抗ZO-1抗体对ZO-1进行检测。
免疫组化分析： 一个先前批次产品以1：500的稀释度在正常人睾丸组织中检测到ZO-1。
研究子类别
神经 & 胶质标记
研究类别
神经科学

Biochem/physiol Actions

其他同源性：大鼠（89％序列同源性）。

Disclaimer

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General description

紧密连接是一种蛋白质复合物，其在上皮细胞和内皮细胞的质膜结构域之间产生细胞间边界。许多紧密连接相关蛋白是膜相关鸟苷酸激酶（MAGUK）家族的成员，包括闭合蛋白和紧密连接蛋白家族ZO-1、ZO-2和ZO-3。这些蛋白被认为具有结构和信号功能，并由三个蛋白-蛋白相互作用模块来特征：PDZ结构域、SH3结构域和鸟苷酸激酶（GuK）结构域。ZO-1可与ZO-2或ZO-3形成复合物。此外，这些蛋白还可以在紧密连接之上与闭合蛋白、咬合蛋白和F-肌动蛋白结合，在它们之间提供肌动蛋白细胞骨架与紧密连接之间的联系。在许多乳腺癌细胞系中，ZO-1表达均明显降低。ZO-2和ZO-3在上皮紧密连接内普遍表达，而ZO-1则在心肌细胞的细胞连接处表达，ZO-2在非上皮组织中不表达。
观测值〜260 kDa

Immunogen

对应于人ZO-1的KLH缀合的线性肽。

Other Notes

浓度：请参考批次特异性浓缩物的分析证书。
浓度：请参考特定批次的数据表。

Physical form

亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。

Preparation Note

自发运之日起，在 2-8°C 条件下可稳定保存1年

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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