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Merck
CN
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主要文件

AB2255

Sigma-Aldrich

抗-GABA B受体R2抗体

serum, from guinea pig

别名:

G protein-coupled receptor 51, G-protein coupled receptor 51, GABA-B receptor 2, gamma-aminobutyric acid (GABA) B receptor, 2, gamma-aminobutyric acid B receptor, 2, GABA-B-R2, GABA(B)R2

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

guinea pig

质量水平

100

抗体形式

serum

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

rhesus macaque, rat

种属反应性（根据同源性预测）

canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), horse (based on 100% sequence homology), rhesus monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), mouse (based on 100% sequence homology)

技术

immunohistochemistry: suitable
western blot: suitable

NCBI登记号

NP_113990

UniProt登记号

O88871

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... GABBR2(9568)

一般描述

γ-氨基丁酸（GABA）是哺乳动物中枢神经紧张的系统中主要的抑制性神经递质。GABA通过离子型[GABA（A/C）]受体发挥其作用，以产生快速的突触抑制，而代谢型[GABA（B）]受体则产生缓慢，延长的抑制信号。GABA（B）受体由两个相关的7跨膜受体GABA（B）受体1和GABA（B）受体2的异二聚体组成。GABA（B）受体1基因被定位到靠近HLA-F基因的HLA I类区域内的染色体6p21.3。多发性硬化、癫痫和精神分裂症的易感基因座也已定位于该区域。该基因的可变剪接产生4个转录物变体。

特异性

该抗体可识别大鼠GABA-B-R2的C端。

免疫原

在大鼠GABA-B-R2的C末端的牛甲状腺球蛋白偶联的线性肽。

应用

抗GABAB受体R2抗体是用于IH & WB的抗GABAB受体R2的抗体。

质量

通过免疫组化对大鼠中脑区浦肯野细胞进行了评估。

免疫组化分析： 该抗体的1:300稀释液在大鼠中脑区域的浦肯野细胞中检测到GABA-B-R2。

目标描述

尽管在计算的105 kDa分子量周围观察到一条条带，但由于该条带与存在的其他非特异性条带相比较弱，因此该抗体不推荐使用蛋白质印迹法。

联系

替代品：AB5394

分析说明

对照
大鼠中脑区的浦肯野细胞

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Yupeng Miao et al.
Nature communications, 12(1), 4518-4518 (2021-07-28)
Multiplexed optical imaging provides holistic visualization on a vast number of molecular targets, which has become increasingly essential for understanding complex biological processes and interactions. Vibrational microscopy has great potential owing to the sharp linewidth of vibrational spectra. In 2017
Liang Zhang et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41(6), 1467-1476 (2015-10-27)
Cortical network hyper-excitability is a common phenotype in mouse models lacking the transcriptional regulator methyl-CPG-binding protein 2 (MeCP2). Here, we implicate enhanced GABAB receptor activity stemming from diminished cortical expression of the GABA transporter GAT-1 in the genesis of this
Chuanyin Hu et al.
Molecular medicine reports, 15(2), 975-980 (2016-12-31)
Chemotherapeutic drugs commonly induce peripheral neuropathic pain, which limit their clinic use. In the present study, the effect of fucoidan on the development of vincristine‑induced neuropathic pain was evaluated and the underlying mechanism was examined. A neuropathy model was established
Khaled Zemoura et al.
The Journal of biological chemistry, 291(41), 21682-21693 (2016-08-31)
GABAB receptors are heterodimeric G protein-coupled receptors, which control neuronal excitability by mediating prolonged inhibition. The magnitude of GABAB receptor-mediated inhibition essentially depends on the amount of receptors in the plasma membrane. However, the factors regulating cell surface expression of
Khaled Zemoura et al.
Molecular neurobiology, 56(2), 1293-1309 (2018-06-09)
The G protein-coupled GABAB receptors, constituted from GABAB1 and GABAB2 subunits, are important regulators of neuronal excitability by mediating long-lasting inhibition. One factor that determines receptor availability and thereby the strength of inhibition is regulated protein degradation. GABAB receptors are
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