AB1580-I
抗-Mu阿片受体抗体
from rabbit, purified by affinity chromatography
别名:
Mu-type opioid receptor, M-OR-1, MOR-1, Mu opiate receptor, Mu opioid receptor, MOP, hMOP, Anti-Opioid Receptor μ
产品名称
抗-Mu阿片受体抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human
species reactivity (predicted by homology)
bovine (based on 100% sequence homology), porcine (based on 100% sequence homology), rat (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... OPRM1(4988)
Analysis Note
通过蛋白质印迹在SH-SY5Y细胞裂解液中进行了评估。
蛋白质印迹分析：0.2 µg/mL的该抗体在10 µg SH-SY5Y细胞裂解液中检测到μ阿片受体。
蛋白质印迹分析：0.2 µg/mL的该抗体在10 µg SH-SY5Y细胞裂解液中检测到μ阿片受体。
Application
使用经验证可用于蛋白质印迹 & IHC（石蜡）的兔多克隆抗体（抗μ阿片受体抗体）检测阿片受体。
免疫组化分析：代表性批次的1:1,000-4,000稀释液在人小脑、小鼠海马、小鼠中脑和大鼠中脑组织中检测到μ阿片受体。
Biochem/physiol Actions
该抗体可识别μ阿片受体的C端。该抗体可识别同工型1（45 kDa）、同工型10（55 kDa）、同工型12（34 kDa）和同工型13（36 kDa）。
General description
μ阿片受体（MOP），也称为μ型阿片受体（MOR-1），是天然和合成阿片类药物的受体，例如β-内啡肽，内吗啡，吗啡，海洛因，DAMGO，芬太尼，埃托啡，丁丙诺啡和美沙酮。MOP充当A类G蛋白偶联受体（GPCR），但其下调途径随激动剂而变化，并且可能独立于也可能不独立于G蛋白偶联。与仅触发低脱敏和内吞作用的合成配体（如吗啡）相反，内源性配体诱导快速脱敏、内吞作用和再循环。与其他GPCR的异源寡聚化可以调节激动剂的结合，信号传导和运输特性。MOP在大脑中表达，并参与神经发生。MOP是大多数临床上重要的阿片类镇痛药的主要生理靶标。
观测值〜70 kDa。计算的分子量为45 kDa，然而，μ阿片受体在蛋白质印迹中显示为~70-90 kDa的条带（Ferrer-Alcon, M., et al. (2004).Molecular Brain Research.121(1-2):114-122）。
Immunogen
KLH偶联的线性肽，对应于人μ阿片受体的C端。
Other Notes
替代品：AB1580
浓度：请参考批次特异性浓缩物的检验报告。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Aysegul Gorur et al.
Journal of cellular physiology, 236(11), 7698-7710 (2021-05-27)
The Mu-opioid receptor (MOR) has been implicated in tumorigenesis and metastasis. Methylnaltrexone (MNTX), an antagonist of MOR, has shown to inhibit tumor growth and metastasis in lung cancer cell lines. The effect of MNTX on other cell lines such as
Lucia Moravčíková et al.
General physiology and biophysics, 37(3), 299-307 (2018-03-29)
SNC80 was designed as a highly selective nonpeptide delta opioid receptor (DOR) agonist. Antidepressant-like and antinociceptive effects of this compound were demonstrated in animal models. Naltrindole was synthetized as a highly selective DOR antagonist. Its antitussive and antinociceptive effects were
Fei Zhu et al.
Neuron, 99(4), 781-799 (2018-08-07)
Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from
Nunzio Vicario et al.
International journal of molecular sciences, 23(11) (2022-06-11)
Chronic neuropathic pain emerges from either central or peripheral lesions inducing spontaneous or amplified responses to non-noxious stimuli. Despite different pharmacological approaches to treat such a chronic disease, neuropathic pain still represents an unmet clinical need, due to long-term therapeutic
Daozhong Jin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(31), 5593-5607 (2023-07-15)
Aberrant activation of presynaptic NMDARs in the spinal dorsal horn is integral to opioid-induced hyperalgesia and analgesic tolerance. However, the signaling mechanisms responsible for opioid-induced NMDAR hyperactivity remain poorly identified. Here, we show that repeated treatment with morphine or fentanyl
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