生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human
种属反应性（根据同源性预测）
bovine (based on 100% sequence homology), porcine (based on 100% sequence homology), rat (based on 100% sequence homology)
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... OPRM1(4988)
一般描述
μ阿片受体（MOP），也称为μ型阿片受体（MOR-1），是天然和合成阿片类药物的受体，例如β-内啡肽，内吗啡，吗啡，海洛因，DAMGO，芬太尼，埃托啡，丁丙诺啡和美沙酮。MOP充当A类G蛋白偶联受体（GPCR），但其下调途径随激动剂而变化，并且可能独立于也可能不独立于G蛋白偶联。与仅触发低脱敏和内吞作用的合成配体（如吗啡）相反，内源性配体诱导快速脱敏、内吞作用和再循环。与其他GPCR的异源寡聚化可以调节激动剂的结合，信号传导和运输特性。MOP在大脑中表达，并参与神经发生。MOP是大多数临床上重要的阿片类镇痛药的主要生理靶标。
特异性
该抗体可识别μ阿片受体的C端。该抗体可识别同工型1（45 kDa）、同工型10（55 kDa）、同工型12（34 kDa）和同工型13（36 kDa）。
免疫原
KLH偶联的线性肽，对应于人μ阿片受体的C端。
应用
使用经验证可用于蛋白质印迹 & IHC（石蜡）的兔多克隆抗体（抗μ阿片受体抗体）检测阿片受体。
免疫组化分析：代表性批次的1:1,000-4,000稀释液在人小脑、小鼠海马、小鼠中脑和大鼠中脑组织中检测到μ阿片受体。
质量
通过蛋白质印迹在SH-SY5Y细胞裂解液中进行了评估。
蛋白质印迹分析：0.2 µg/mL的该抗体在10 µg SH-SY5Y细胞裂解液中检测到μ阿片受体。
蛋白质印迹分析：0.2 µg/mL的该抗体在10 µg SH-SY5Y细胞裂解液中检测到μ阿片受体。
目标描述
观测值〜70 kDa。计算的分子量为45 kDa，然而，μ阿片受体在蛋白质印迹中显示为~70-90 kDa的条带（Ferrer-Alcon, M., et al. (2004).Molecular Brain Research.121(1-2):114-122）。
联系
替代品：AB1580
其他说明
浓度：请参考批次特异性浓缩物的检验报告。
Not finding the right product?
Try our 产品选型工具.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Aysegul Gorur et al.
Journal of cellular physiology, 236(11), 7698-7710 (2021-05-27)
The Mu-opioid receptor (MOR) has been implicated in tumorigenesis and metastasis. Methylnaltrexone (MNTX), an antagonist of MOR, has shown to inhibit tumor growth and metastasis in lung cancer cell lines. The effect of MNTX on other cell lines such as
Fei Zhu et al.
Neuron, 99(4), 781-799 (2018-08-07)
Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from
Lucia Moravčíková et al.
General physiology and biophysics, 37(3), 299-307 (2018-03-29)
SNC80 was designed as a highly selective nonpeptide delta opioid receptor (DOR) agonist. Antidepressant-like and antinociceptive effects of this compound were demonstrated in animal models. Naltrindole was synthetized as a highly selective DOR antagonist. Its antitussive and antinociceptive effects were
Nunzio Vicario et al.
International journal of molecular sciences, 23(11) (2022-06-11)
Chronic neuropathic pain emerges from either central or peripheral lesions inducing spontaneous or amplified responses to non-noxious stimuli. Despite different pharmacological approaches to treat such a chronic disease, neuropathic pain still represents an unmet clinical need, due to long-term therapeutic
Daozhong Jin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(31), 5593-5607 (2023-07-15)
Aberrant activation of presynaptic NMDARs in the spinal dorsal horn is integral to opioid-induced hyperalgesia and analgesic tolerance. However, the signaling mechanisms responsible for opioid-induced NMDAR hyperactivity remain poorly identified. Here, we show that repeated treatment with morphine or fentanyl
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门