AB15332
抗烟碱乙酰胆碱受体α7抗体
Chemicon®, from rabbit
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
rat, mouse, human
Citations:
3
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗烟碱乙酰胆碱受体α7抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, mouse, human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Chrna7(11441)
Application
质量控制测试
通过蛋白质印迹在大鼠脑组织裂解液中进行了评估。蛋白质印迹分析：该抗体的1:500稀释液在大鼠脑组织裂解液中检测到烟碱乙酰胆碱受体7。
通过蛋白质印迹在大鼠脑组织裂解液中进行了评估。蛋白质印迹分析：该抗体的1:500稀释液在大鼠脑组织裂解液中检测到烟碱乙酰胆碱受体7。
Biochem/physiol Actions
该兔多克隆抗体可特异性检测烟碱受体7。它靶向C末端一半的28个氨基酸的表位。
General description
神经元乙酰胆碱受体亚基α -7（UniProt：P36544；也称-烟碱受体α 7，由人类CHRNA7（也称为NACHRA7）基因（基因ID：1139）编码。烟碱乙酰胆碱受体是阳离子选择性、配体门控的离子通道，负责介导快速神经传递。它们分布在肌细胞的突触后膜上。在中枢神经系统中也发现了类似的神经元型乙酰胆碱受体，并参与广泛的生理和病理功能。它们是由7、8和9组成的同型五聚体，或者由26与 β2 β4或9与10亚基组成的异型五聚体。它们调节钠、钾和钙离子在细胞膜上的流动。配体与这些受体的结合会触发神经元AChR在功能上不同的静息、开放和脱敏状态之间的三级构象转变。烟碱AChR 7是一种单程、同源五聚体、跨膜糖蛋白，合成时先形成带一个信号肽（氨基酸1-22）的前体，随后切割为成熟蛋白质，其中包含一个胞外结构域（氨基酸23-230）、四个跨膜结构域（氨基酸231-255；262-280；296-317；和470-490）和一个胞质结构域（氨基酸318-469）。（参考文献：Ho, TN., et al. (2020).Front.Neurosci. 14; 609005; Unwin, N. (2013).Q. Rev. Biophys.46(4); 283-322）。
Immunogen
KLH偶联的线性肽，对应烟碱受体7的C端一半的28个氨基酸。
Other Notes
替代：AB5637
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
纯化的兔多克隆抗体，溶于含有0.02 M磷酸盐缓冲液（pH 7.6）、0.25 M NaCl和0.1%叠氮化钠的缓冲液中。
Preparation Note
建议储存：+2°C至+8°C。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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