跳转至内容
Merck
CN
所有图片(1)

文件

AB1254

Sigma-Aldrich

抗细胞色素P450酶CYP3A4抗体

serum, Chemicon®

登录查看公司和协议定价

别名:
Anti-Anti-CP33, Anti-Anti-CP34, Anti-Anti-CYP3A, Anti-Anti-CYP3A3, Anti-Anti-CYPIIIA3, Anti-Anti-CYPIIIA4, Anti-Anti-HLP, Anti-Anti-NF-25, Anti-Anti-P450C3, Anti-Anti-P450PCN1, Anti-Anti-VDDR3
UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

抗体形式

serum

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

human, pig

种属反应性(根据同源性预测)

mammals, rat

制造商/商品名称

Chemicon®

技术

immunohistochemistry: suitable
western blot: suitable

NCBI登记号

UniProt登记号

运输

dry ice

靶向翻译后修饰

unmodified

基因信息

human ... CYP3A4(1576)

特异性

兔多克隆血清检测人和大鼠体内CYP3A4;通过所用免疫原的序列同源性,可以预期与CYP3A7、3A6V4;3A2V1、3A8、3A9的交叉反应性,但此时尚未测试。

免疫原

含有来自人CYP3A4的TVSGA的C端序列的合成肽。该肽与KLH偶联。

应用

抗细胞色素P450酶CYP3A4抗体可检测细胞色素P450酶CYP3A4水平 & 已出版 & 经过验证可用于IH & WB。
研究子类别
酶&生物化学
研究类别
代谢
蛋白质印迹: 1:1000-1:2000:使用微粒体膜级分,检测~54 kDa的条带;也可能存在其他条带。 抗体已成功用于LICOR荧光westerns检测CYP3A4。

免疫组化:10%福尔马林固定,石蜡包埋的组织1:200-1:400,建议使用微波-柠檬酸抗原回收。

最佳工作稀释度必须由最终用户确定。

目标描述

57 kDa

外形

兔抗血清。 不含防腐剂的液体。
未纯化

储存及稳定性

自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品,在融化后和取下盖子之前,将原始小瓶进行离心。

分析说明

对照
肝组织

其他说明

浓度:请参考批次特异性浓缩物的检验报告。

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Ulrik Kræmer Sundekilde et al.
Toxicology, 469, 153121-153121 (2022-02-11)
The circadian rhythm has profound effect on the body, exerting effects on diverse events like sleep-wake patterns, eating behavior and hepatic detoxification. The cytochrome p450 s (Cyps) is the main group of enzymes responsible for detoxification. However, the underlying mechanisms
Nicolas Quesnot et al.
Archives of toxicology, 92(10), 3077-3091 (2018-08-29)
CYP2E1 activity is measured in vitro and in vivo via hydroxylation of the Chlorzoxazone (CHZ) producing the 6-hydroxychlorzoxazone (OH-CHZ) further metabolized as a glucuronide excreted in urine. Thus, the quantification of the OH-CHZ following enzymatic hydrolysis of CHZ-derived glucuronide appears
Konstantin Neukirch et al.
Journal of medicinal chemistry, 64(15), 11496-11526 (2021-07-20)
Endogenous long-chain metabolites of vitamin E (LCMs) mediate immune functions by targeting 5-lipoxygenase (5-LOX) and increasing the systemic concentrations of resolvin E3, a specialized proresolving lipid mediator. SAR studies on semisynthesized analogues highlight α-amplexichromanol (27a), which allosterically inhibits 5-LOX, being
Els Van Peer et al.
Basic & clinical pharmacology & toxicology, 114(5), 387-394 (2013-11-15)
Despite the increasing use of the minipig as a non-rodent species in general and juvenile toxicity studies, knowledge on their biotransformation processes and their ontogeny is scarce. Such data are prerequisite for the correct interpretation of non-clinical studies in this
Shivani Ruparel et al.
Pain, 154(11), 2363-2371 (2013-07-23)
Endogenous TRPV1 agonists such as oxidized linoleic acid metabolites (OLAMs) and the enzymes releasing them [eg, cytochrome P450 (CYP)] are up-regulated after inflammation in the rat. However, it is not known whether such agonists are elevated in human inflammatory pain

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门