AB1254
抗细胞色素P450酶CYP3A4抗体
serum, Chemicon®
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
human, pig
Citations:
21
Technique(s):
immunohistochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗细胞色素P450酶CYP3A4抗体, serum, Chemicon®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, pig
species reactivity (predicted by homology)
mammals, rat
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CYP3A4(1576)
Analysis Note
对照
肝组织
肝组织
Application
抗细胞色素P450酶CYP3A4抗体可检测细胞色素P450酶CYP3A4水平 & 已出版 & 经过验证可用于IH & WB。
研究子类别
酶&生物化学
酶&生物化学
研究类别
代谢
代谢
蛋白质印迹： 1:1000-1:2000：使用微粒体膜级分，检测~54 kDa的条带；也可能存在其他条带。 抗体已成功用于LICOR荧光westerns检测CYP3A4。
免疫组化：10%福尔马林固定，石蜡包埋的组织1:200-1:400，建议使用微波-柠檬酸抗原回收。
最佳工作稀释度必须由最终用户确定。
免疫组化：10%福尔马林固定，石蜡包埋的组织1:200-1:400，建议使用微波-柠檬酸抗原回收。
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
兔多克隆血清检测人和大鼠体内CYP3A4；通过所用免疫原的序列同源性，可以预期与CYP3A7、3A6V4；3A2V1、3A8、3A9的交叉反应性，但此时尚未测试。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
57 kDa
Immunogen
含有来自人CYP3A4的TVSGA的C端序列的合成肽。该肽与KLH偶联。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
兔抗血清。 不含防腐剂的液体。
未纯化
Preparation Note
自收到之日起在-20°C可稳定保存1年。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Manuel Vlach et al.
Cells, 11(23) (2022-12-12)
The goal of this study was to establish a procedure for gene delivery mediated by cationic liposomes in quiescent differentiated HepaRG™ human hepatoma cells. We first identified several cationic lipids promoting efficient gene transfer with low toxicity in actively dividing
Shivani Ruparel et al.
Pain, 154(11), 2363-2371 (2013-07-23)
Endogenous TRPV1 agonists such as oxidized linoleic acid metabolites (OLAMs) and the enzymes releasing them [eg, cytochrome P450 (CYP)] are up-regulated after inflammation in the rat. However, it is not known whether such agonists are elevated in human inflammatory pain
Up-regulating CYP3A4 expression in C3A cells by transfection with a novel chimeric regulator of hPXR-p53-AD.
Chen, F; Rao, XH; Yang, JL; Pan, MX; Gao, Y; Li, ZL; Li, Y; Zhu, YF; Wang, Y
Testing null
Nicolas Quesnot et al.
Archives of toxicology, 92(10), 3077-3091 (2018-08-29)
CYP2E1 activity is measured in vitro and in vivo via hydroxylation of the Chlorzoxazone (CHZ) producing the 6-hydroxychlorzoxazone (OH-CHZ) further metabolized as a glucuronide excreted in urine. Thus, the quantification of the OH-CHZ following enzymatic hydrolysis of CHZ-derived glucuronide appears
Ulrik Kræmer Sundekilde et al.
Toxicology, 469, 153121-153121 (2022-02-11)
The circadian rhythm has profound effect on the body, exerting effects on diverse events like sleep-wake patterns, eating behavior and hepatic detoxification. The cytochrome p450 s (Cyps) is the main group of enzymes responsible for detoxification. However, the underlying mechanisms
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