质量水平
检测方案
≥98% (HPLC)
形式
liquid
效能
16 nM IC50
16 nM Ki
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
运输
wet ice
储存温度
−20°C
InChI
1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H
InChI key
NJNKPVPFGLGHPA-UHFFFAOYSA-N
一般描述
A potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC50 = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.
生化/生理作用
Cell permeable: yes
Primary Target
P38β
P38β
Product competes with ATP.
Reversible: yes
Target Ki: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
包装
Packaged under inert gas
Please refer to vial label for lot-specific concentration.
警告
Toxicity: Irritant (B)
外形
A 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.
重悬
Following initial thaw, aliquot and freeze (-20°C).
其他说明
Ajizian, S.J., et al. 1999. J. Infect. Dis.179, 939.
Singh, R.P., et al. 1999. J. Biol. Chem.274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res.48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem.5, 49.
Jiang, Y., et al. 1996. J. Biol. Chem.271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem.271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun.228, 334.
Lee, L.C., et al. 1994. Nature372, 739.
Singh, R.P., et al. 1999. J. Biol. Chem.274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res.48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem.5, 49.
Jiang, Y., et al. 1996. J. Biol. Chem.271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem.271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun.228, 334.
Lee, L.C., et al. 1994. Nature372, 739.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Xiao Cui et al.
Cell biology international, 44(9), 1811-1819 (2020-05-07)
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is caused by the interaction of genetic and environmental factors. Current studies have shown that Fc-receptor like-3 (FCRL3) is closely related to MS, but the specific role
Matriptase drives dissemination of ovarian cancer spheroids by a PAR-2/PI3K/Akt/MMP9 signaling axis.
Nisha R Pawar et al.
The Journal of cell biology, 222(11) (2023-09-22)
The transmembrane serine protease matriptase is a key regulator of both barrier-disruptive and protective epithelial cell-cell interactions. Elevated matriptase is a consistent feature of epithelial ovarian cancers (OvCa), where multicellular spheroids shed from the primary tumor into the peritoneal cavity
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