推荐产品
产品名称
寡霉素, A mixture of A, B, and C isomers.
质量水平
方案
≥90% (mixture of A, B, and C isomers, HPLC)
表单
powder
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
颜色
white
运输
ambient
储存温度
−20°C
InChI
1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+
InChI key
MNULEGDCPYONBU-ZUSSGZTJSA-N
一般描述
A、B和C异构体的混合物。一种大环内酯类抗生素，可抑制膜结合线粒体ATP合成酶，从而阻止磷酸基转移。诱导人淋巴母细胞和其他哺乳动物细胞凋亡。
生化/生理作用
主要靶标
膜结合线粒体ATP酶（F1）
膜结合线粒体ATP酶（F1）
产品不与ATP竞争。
可逆：否
细胞渗透性：否
警告
毒性：刺激性（B）
重悬
在重悬后分装并冻存于冰箱（-20°C。储备溶液在-20°C下可稳定保存2个月。
其他说明
Wolvetang, E.J., et al. 1994.FEBS Lett.339, 40.
Amoroso, S., et al. 1993.J. Pharmacol.Exp.Ther.264, 515.
Brustovetsky, N.N., et al. 1993.FEBS Lett.315, 233.
Nagamune, H., et al. 1993.Biochim.Biophys.Acta1141, 231.
Amoroso, S., et al. 1993.J. Pharmacol.Exp.Ther.264, 515.
Brustovetsky, N.N., et al. 1993.FEBS Lett.315, 233.
Nagamune, H., et al. 1993.Biochim.Biophys.Acta1141, 231.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Birte Plitzko et al.
Bio-protocol, 8(10), e2850-e2850 (2018-05-20)
Mammalian cells generate ATP by mitochondrial (oxidative phosphorylation) and non-mitochondrial (glycolysis) metabolism. Cancer cells are known to reprogram their metabolism using different strategies to meet energetic and anabolic needs ( Koppenol et al., 2011 ; Zheng, 2012). Additionally, each cancer
Thomas A Ryan et al.
The EMBO journal, 39(11), e102539-e102539 (2020-04-21)
Multiple mitochondrial quality control pathways exist to maintain the health of mitochondria and ensure cell homeostasis. Here, we investigate the role of the endosomal adaptor Tollip during the mitochondrial stress response and identify its interaction and colocalisation with the Parkinson's
Shuo Wan et al.
Frontiers in immunology, 12, 685984-685984 (2021-08-10)
Angiostrongylus cantonensis (AC), which parasitizes in the brain of the non-permissive host, such as mouse and human, is an etiologic agent of eosinophilic meningitis. Excretory-secretory (ES) products play an important role in the interaction between parasites and hosts' immune responses.
Shirong Yang et al.
Cancer communications (London, England), 41(8), 695-714 (2021-06-24)
Mitochondria are key regulators in cell proliferation and apoptosis. Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis. This study aimed to investigate whether mitochondrial transcription factor A (TFAM), a key regulator of mitochondrial DNA transcription and replication
Pengcheng Zhang et al.
iScience, 25(1), 103709-103709 (2022-01-25)
SIRT1 is a metabolic sensor regulating energy homeostasis. The present study revealed that mice with selective overexpression of human SIRT1 in adipose tissue (Adipo-SIRT1) were protected from high-fat diet (HFD)-induced metabolic abnormalities. Adipose SIRT1 was enriched at mitochondria-ER contacts (MERCs)
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