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Merck
CN

48-680MAG

MILLIPLEX® Multi-Pathway Signaling Panel

Premixed Multi-Pathway Phosphoprotein 9-Plex Cell Signaling Panel

别名:

ERK Cell Signaling Assay, Luminex® Cell Signaling Assay, Millipore Cell Signaling Assay, MAPK STAT TCR assay, multi-pathway signaling panel, multi-target phosphorylation panel, phosphoprotein multiplex assay, rat cell signaling panel, rat intracellular signaling biomarkers

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UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000

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产品名称

MILLIPLEX® Multi-Pathway Signaling Panel, Premixed Multi-Pathway Phosphoprotein 9-Plex Cell Signaling Panel

Quality Level

200

species reactivity

rat, mouse, human

technique(s)

multiplexing: suitable

input

cell lysate

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

相关类别

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 9 analytes in human, mouse, or rat cell lysate samples.

Analytes Included: CREB (pS133), ERK (pT185/pY187), NFκB (pS536), JNK (pT183/pY185), p38 (Thr180/Tyr182), p70S6K (Thr412), STAT3 (pS727), STAT5A/B (pY694/699), Akt (pS473)

Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™ Control Assays).
Research Category
Cell Signaling
Research Sub Category
Oncology

Biochem/physiol Actions

Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

  • Simultaneously detect 9 phosphorylated proteins across multiple signaling pathways
  • Covers key pathways including MAPK, STAT, Akt, and NFκB
  • Magnetic bead-based format ensures reproducibility and efficient processing
  • Compatible with cell lysates from diverse experimental conditions
  • Ideal for signal transduction, oncology, immunology, and toxicology research
  • Fast, convenient alternative to Western Blotting and immunoprecipitation procedures

General description

This panel includes phosphorylated proteins involved in multiple signaling pathways that regulate cell survival, proliferation, inflammation, and transcriptional activity. CREB (pS133) is a transcription factor activated by cAMP signaling. ERK (pT185/pY187), JNK (pT183/pY185), and p38 (Thr180/Tyr182) are key components of the MAPK pathway. Akt (pS473) regulates cell survival and metabolism. NFκB (pS536) controls inflammatory and immune responses. p70S6K (Thr412) is involved in protein synthesis, while STAT3 (pS727) and STAT5A/B (pY694/699) mediate cytokine signaling and immune regulation

Preparation Note

Recommended storage for kit components is 2 - 8°C

Legal Information

Luminex is a registered trademark of Luminex Corp
MAPMATE is a trademark of Merck KGaA, Darmstadt, Germany
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

signalword

Danger

存储类别

10 - Combustible liquids

wgk

WGK 3

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - ED ENV 1 - Eye Dam. 1 - Skin Irrit. 2

法规信息

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