440025
Luteolin
≥90% (HPLC), antioxidant flavonoid, solid
别名:
Luteolin, 3ʹ,4ʹ,5,7-Tetrahydroxyflavone
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关于此项目
经验公式（希尔记法）:
C15H10O6
化学文摘社编号:
分子量:
286.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
产品名称
Luteolin, An antioxidant flavonoid and a free radical scavenger.
Quality Segment
description
Merck USA index - 14, 5614
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
aqueous base: 1.4 mg/mL, DMSO: 7 mg/mL, ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
[o]1c2c([c](cc1c3cc(c(cc3)O)O)=O)c(cc(c2)O)O
InChI
1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
InChI key
IQPNAANSBPBGFQ-UHFFFAOYSA-N
General description
An antioxidant flavonoid and a free radical scavenger. Inhibits rat liver cytosolic glutathione S-transferase activity. Also shows cytotoxic effects on Raji lymphoma cells. Incubation of the non-tumor cell line C3H10T½CL8 with luteolin results in induction of p53 accumulation and apoptosis, with apoptosis occurring at the G2/M phase of the cell cycle. Also shown to inhibit TPL2 kinase.
Biochem/physiol Actions
Cell permeable: no
Primary Target
rat liver cytosolic glutathione S-transferase activity
rat liver cytosolic glutathione S-transferase activity
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
Other Notes
Kim, J.E., et al. 2011. J. Pharmacol. Exp. Ther.in press.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.
Korkina, L.G., and Afanasev, I.B. 1997. Adv. Pharmacol.38, 151.
Plaumann, B., et al. 1996. Oncogene 13, 1605.
Ramanathan, R., et al. 1994. Free Radic. Biol. Med.16, 43.
Shimoi, L., et al. 1994. Carcinogenesis15, 2669.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable