一般描述
Research area: CELL CYCLE
Recombinant, human androgen receptor (AR) fused at the N-terminus to a Flag-Tag sequence and at the C-terminus to His•Tag sequence, expressed in S. frugiperda insect cells expressed using a baculovirus expression system, and purified by affinity chromatography. It is located at X chromosome and is expressed in various tissues. It consists of three primary functional domains: the N-terminal transcriptional regulation domain, the DNA binding domain (DBD), and the ligand binding domain.
Recombinant, human androgen receptor (AR) fused at the N-terminus to a Flag-Tag sequence and at the C-terminus to His•Tag sequence, expressed in S. frugiperda insect cells expressed using a baculovirus expression system, and purified by affinity chromatography. It is located at X chromosome and is expressed in various tissues. It consists of three primary functional domains: the N-terminal transcriptional regulation domain, the DNA binding domain (DBD), and the ligand binding domain.
生化/生理作用
The androgen receptor (AR) has significant biological effects on bone, muscle, prostate, adipose tissue, as well as on the reproductive, cardiovascular, immune, neural, and haemopoietic systems.
The activity of androgen is mediated by the binding of the intracellular androgen receptor which, when activated, translocates to the nucleus and modulates specific gene transcription by interaction with cis-acting hormone response elements in the target genes.
The activity of androgen is mediated by the binding of the intracellular androgen receptor which, when activated, translocates to the nucleus and modulates specific gene transcription by interaction with cis-acting hormone response elements in the target genes.
警告
Toxicity: Standard Handling (A)
单位定义
1.0 unit is equivalent to 1 ng protein. 20 units are sufficient for a gel-mobility shift assay and 100 units are sufficient for a protein-protein interaction assay.
One unit is defined as 1 ng purified protein.
外形
In 100 mM KCl, 20 mM Tris-HCl, 1 mM DTT, 200 µM EDTA, 20% glycerol, pH 8.0.
重悬
Following initial thaw, aliquot and freeze (-70°C).
其他说明
Chen, G., et al. 2005. Prostate63, 395.
Estebanez-Perpina, E., et al. 2005, J. Biol. Chem.280, 8060.
Gao, S., et al. 2005. Mol. Endocrinol.19, 1792.
Hillmer, A.M., et al. 2005. Am. J. Hum. Genet.77, 140.
Kinoshita, M., et al. 2005, Int. J. Urol.12, 390.
Lim, J.T., et al. 2005. Proc. Natl. Acad. Sci. U.S.A.102, 5156;
Marques, R.B., et al. 2005. Int. J. Cancer117, 221;
Metzger, E., et al. 2005. Nature437, 436;
Murthy, S., et al. 2005. Prostate64, 362;
Chang, C., et al. 1992. Proc. Natl. Acad. Sci. USA89, 5946.
Estebanez-Perpina, E., et al. 2005, J. Biol. Chem.280, 8060.
Gao, S., et al. 2005. Mol. Endocrinol.19, 1792.
Hillmer, A.M., et al. 2005. Am. J. Hum. Genet.77, 140.
Kinoshita, M., et al. 2005, Int. J. Urol.12, 390.
Lim, J.T., et al. 2005. Proc. Natl. Acad. Sci. U.S.A.102, 5156;
Marques, R.B., et al. 2005. Int. J. Cancer117, 221;
Metzger, E., et al. 2005. Nature437, 436;
Murthy, S., et al. 2005. Prostate64, 362;
Chang, C., et al. 1992. Proc. Natl. Acad. Sci. USA89, 5946.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 1
Androgen Receptor Structure, Function and Biology: From Bench to Bedside
R Davey and M Grossmann
The Clinical Biochemist. Reviews / Australian Association of Clinical Biochemists, 37(1) , 3?15-3?15 (2016)
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