14-439-M
MAP Kinase 1/Erk1 Protein, active, 10 µg
Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.
别名:
ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK
产品名称
MAP Kinase 1/Erk1 Protein, active, 10 µg, Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.
biological source
human
recombinant
expressed in E. coli
form
liquid
mol wt
Mw 69.9 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
color
colorless
solubility
water: soluble
NCBI accession no.
UniProt accession no.
Quality Level
Gene Information
human ... MAPK3(5595)
Analysis Note
routinely evaluated by phosphorylation of MBP
Biochem/physiol Actions
Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.
General description
Research area: Cell Signaling
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Packaging
Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.
Physical form
Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 2
Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
Lucinda F Reynolds et al.
The Journal of biological chemistry, 279(18), 18239-18246 (2004-02-07)
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection. Previous work has shown that Vav1 transduces T cell receptor (TCR)
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