14-439-M
MAP Kinase 1/Erk1 Protein, active, 10 µg
Active, recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag, for use in Kinase Assays.
别名:
ERT1, Extracellular signal-regulated kinase 2 (ERK-2), MAPK 1, Mitogen-activated protein kinase 1, p44 MAPK
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所有图片(2)
About This Item
UNSPSC代码:
12352202
eCl@ss:
32160405
NACRES:
NA.32
生物来源
human
质量水平
重组
expressed in E. coli
形式
liquid
分子量
Mw 69.9 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
颜色
colorless
溶解性
water: soluble
NCBI登记号
UniProt登记号
基因信息
human ... MAPK3(5595)
一般描述
Research area: Cell Signaling
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
生化/生理作用
Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.
包装
Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.
质量
routinely evaluated by phosphorylation of MBP
外形
Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Y Zhang et al.
The Journal of biological chemistry, 276(24), 20913-20923 (2001-03-30)
Ultraviolet light A (UVA) plays an important role in the etiology of human skin cancer, and UVA-induced signal transduction has a critical role in UVA-induced skin carcinogenesis. The upstream signaling pathways leading to p70(S6K) phosphorylation and activation are not well
Lucinda F Reynolds et al.
The Journal of biological chemistry, 279(18), 18239-18246 (2004-02-07)
Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection. Previous work has shown that Vav1 transduces T cell receptor (TCR)
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