生物来源
human
质量水平
重组
expressed in E. coli
分子量
Mw 67.7 kDa
制造商/商品名称
Upstate®
技术
activity assay: suitable (kinase)
UniProt登记号
基因信息
human ... MAPK14(1432)
一般描述
N-terminal GST tagged, recombinant, full length p38α/SAPK2a
Product Source: expressed in E. coli
生化/生理作用
Protein Target: p38α/SAPK2a
Target Sub-Family: CMGC
包装
Also available in 250μg size (2x125μg) - Call for pricing and availability. Please reference catalog number 14-251M when ordering the 250μg size.
质量
Routinely evaluated by phosphorylation of MBP
外形
Glutathione-agarose
储存及稳定性
6 months at -20°C
其他说明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
WGK
WGK 2
Y N Doza et al.
FEBS letters, 364(2), 223-228 (1995-05-08)
A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of
A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.
Ben-Levy, R, et al.
The Embo Journal, 13, 3302-3311 (1994)
A Cuenda et al.
FEBS letters, 364(2), 229-233 (1995-05-08)
A class of pyridinyl imidazoles inhibit the MAP kinase homologue, termed here reactivating kinase (RK) [Lee et al. (1994) Nature 372, 739-746]. We now show that one of these compounds (SB 203580) inhibits RK in vitro (IC50 = 0.6 microM)
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