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ligand
carboxymethyl
质量水平
描述
weak cation exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
无菌性
sterile (Caustic Stable)
产品线
Fractogel®
表单
resin
特殊分析物
MAbs
参数
300 cm/hr flow rate
8 bar max. pressure
基质活性基团
methacrylate
平均粒径
40-90 μm
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此商品 | 57030U | 57265 | 57044 |
|---|---|---|---|
| application(s) environmental | application(s) environmental | application(s) food and beverages | application(s) environmental |
| material UHMW PE frit, polypropylene tube | material UHMW PE frit, polypropylene tube | material PTFE frit, polypropylene tube | material polypropylene tube |
| agency suitable for DIN 38407-42 | agency suitable for DIN 38407-42, suitable for EPA 1633, suitable for EPA 533, suitable for EPA 537.1, suitable for EPA ACB B21-02, suitable for EPA ACB B23-05b, suitable for EPA OTM-45, suitable for GB 31604.35-2016, suitable for ISO 21675 2019, suitable for ISO 25101, suitable for ISO/CEN 15968-2010 | agency - | agency - |
| reg. compliance suitable for FDA C-010.02 | reg. compliance suitable for FDA C-010.02 | reg. compliance - | reg. compliance - |
| product line Visiprep™ | product line Visiprep™ | product line Visiprep™ | product line - |
一般描述
特点和优势
- Good resolution between monomers and aggregates
- Efficient aggregate and HCP removal combined with high yield
- Compatibility with 2.5 % (v/v) aqueous benzyl alcohol containing 150 mM NaCl storage solution
Due to the titration behavior, the ion exchange capacity can be used from pH 6 to pH 12. The separation of proteins is based on reversible electrostatic interactions between the negatively charged regions of the proteins′ surface and the support. Proteins are retained efficiently on Fractogel® EMD COO- (M) when the pH of the buffer is about 1 unit below their isoelectric points (pl).
The strength of the binding depends on the following:
- the buffer system
- pH value of the buffer which determines the surface charge of the protein
- the degree of the ionization of the functional groups of the exchanger
- the concentration of the counter ions
- the charge density on the support (protein binding capacity)
包装
- 1.16886.0100: Fractogel® EMD COO- (M) Resin 100ml
- 1.16886.0010: Fractogel® EMD COO- (M) Resin 10ml
- 1.16886.0500: Fractogel® EMD COO- (M) Resin 500ml
- 1.16886.5000: Fractogel® EMD COO- (M) Resin 5L
分析说明
Microscopic evaluation: Uniform spherical particles,no agglomerates,no fines
Extractable matter (water): ≤ 0.05 %
Cerium: ≤ 10 µg/g
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Particle size (d10): 37 - 45 µm
Particle size (d50): 48 - 60 µm
Particle size (d90): 63 - 77 µm
Colony forming units (TAMC + TYMC): ≤ 100 CFU/ml
Endotoxins: ≤ 1.00 EU/ml
Protein binding capacity (lysozyme): 80 - 120 mg/ml
Functional test (b:a): ≤ 0.30
Functional test (c:d): ≤ 0.70
Functional test: Separation of chymotrypsinogen A, cytochrome C and lysozyme
法律信息
警示用语：
Warning
危险声明
危险分类
Flam. Liq. 3
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
95.0 °F
闪点(°C)
35 °C
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