1.04672
胆固醇
EMPROVE® EXPERT, Ph. Eur., BP, JP, NF
别名:
3β-羟基-5-胆甾烯, 5-胆甾烯-3β-醇
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经验公式（希尔记法）:
C27H46O
化学文摘社编号:
分子量:
386.65
UNSPSC Code:
12352104
Beilstein/REAXYS Number:
1915888
MDL number:
产品名称
胆固醇, EMPROVE® EXPERT, Ph. Eur., BP, JP, NF
InChI key
HVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
biological source
synthetic
agency
BP
JP
NF
Ph. Eur.
product line
EMPROVE® EXPERT
form
powder
bp
360 °C (lit.)
mp
~141 °C
147-149 °C (lit.)
density
1.067 g/mL at 25 °C (lit.)
suitability
suitable for (Suitable for formulation and manufacturing use)
application(s)
advanced drug delivery
controlled release
liquid formulation
parenterals
pharmaceutical
storage temp.
15-25°C
Quality Level
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Biochem/physiol Actions
所有生物膜的主要成分；总脑脂质中约25%为胆固醇。
Application
Cholesterol is a major component of all biological cell membranes and is used as a stabilizer of lipid bilayers in many lipid-based formulations for the delivery of different APIs, such as small molecules and nucleic acids.
Synthetic cholesterol, Ph Eur, BP, JP, NF is ultra-pure and therefore suitable for divers formulations applications. Due to low batch to batch variability, very high purity, and lack of biological components, this product is optimal for highly sensitive applications such as nucleic acid delivery.
With a newly optimized manufacturing process, this product is available in quantities from grams to tons to support your development progress. A dual sourcing option is also possible.
Synthetic cholesterol, Ph Eur, BP, JP, NF is ultra-pure and therefore suitable for divers formulations applications. Due to low batch to batch variability, very high purity, and lack of biological components, this product is optimal for highly sensitive applications such as nucleic acid delivery.
With a newly optimized manufacturing process, this product is available in quantities from grams to tons to support your development progress. A dual sourcing option is also possible.
Disclaimer
The substance 1.04672 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.
General description
A GMP-scalable process which yields a high-quality lipid is essential to lipidic drug product development and manufacturing. We are highly specialized in synthesizing top-quality GMP lipids for pharmaceutical applications and gene therapy, focusing on tailored manufacturing to meet your specific needs. We also offer an off-the-shelf catalog with optimized stability, solubility, and handling characteristics.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
SyntheChol is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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