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Merck
CN
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文件

07-681

Sigma-Aldrich

抗磷酸化AMPK α(Thr172) 抗体

Upstate®, from rabbit

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UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

100

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

human, rat

制造商/商品名称

Upstate®

技术

western blot: suitable

同位素/亚型

IgG

NCBI登记号

NM_006251.5
NM_206907.3

UniProt登记号

Q13131

运输

wet ice

靶向翻译后修饰

phosphorylation (pThr172)

基因信息

human ... PRKAA1(5562)

特异性

可识别磷酸化AMPKα。

免疫原

KLH偶联的合成肽，对应于人AMP活化蛋白激酶α2（AMPKα2）的磷酸化Thr172周围的氨基酸。

应用

抗磷酸化AMPK α（Tyr342）抗体是针对磷酸化AMPKα（Tyr342）的抗体，可用于WB。

质量

已通过免疫印迹对过夜饥饿的HEK293 细胞和部分纯化的大鼠肝脏AMPK的RIPA裂解液进行了常规评估

目标描述

Mr 63 kDa

外形

形式：纯化

分析说明

对照
血清饥饿HEK293 细胞

其他说明

浓度：请参考批次特异性浓缩物的检验报告。

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

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B E Kemp et al.
Biochemical Society transactions, 31(Pt 1), 162-168 (2003-01-28)
The AMP-activated protein kinase (AMPK) is a metabolic-stress-sensing protein kinase that regulates metabolism in response to energy demand and supply by directly phosphorylating rate-limiting enzymes in metabolic pathways as well as controlling gene expression.
J F P Wojtaszewski et al.
Biochemical Society transactions, 31(Pt 6), 1290-1294 (2003-12-04)
The AMPK (5'AMP-activated protein kinase) is becoming recognized as a critical regulator of energy metabolism. However, many of these effects in muscle metabolism have been ascribed to AMPK based on the use of the unspecific activator AICAR (5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside). Using mouse
Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis.
Rutter, Guy A, et al.
The Biochemical Journal, 375, 1-16 (2003)
Tue L Nielsen et al.
Molecular genetics and metabolism, 123(1), 21-27 (2017-11-28)
McArdle disease (glycogen storage disease type V) is an inborn error of skeletal muscle metabolism, which affects glycogen phosphorylase (myophosphorylase) activity leading to an inability to break down glycogen. Patients with McArdle disease are exercise intolerant, as muscle glycogen-derived glucose
Mathias Fasshauer et al.
Biochimie, 86(11), 779-784 (2004-12-14)
Several adipocyte-secreted factors have been demonstrated to potentially link obesity, insulin resistance, and cardiovascular disease. Among those, adiponectin is an insulin-sensitizing and anti-inflammatory adipokine, concentrations of which are decreased in obesity-associated metabolic and vascular disorders. Recently, two adiponectin receptors (AdipoR)
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