生物来源
rabbit
质量水平
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
纯化方式
affinity chromatography
种属反应性
mouse, human, rat
制造商/商品名称
Upstate®
技术
western blot: suitable
同位素/亚型
IgG
NCBI登记号
UniProt登记号
运输
dry ice
靶向翻译后修饰
unmodified
基因信息
human ... PTPRA(5786)
mouse ... Ptpra(19262)
rat ... Ptpra(25167)
特异性
PTP alpha isoform
免疫原
N-terminal GST-tagged fusion protein corresponding to residues 505-793 of human PTP alpha (complete D2 catalytic domain).
应用
Anti-PTPα Antibody detects level of PTPα & has been published & validated for use in WB.
Research Category
Signaling
Signaling
Research Sub Category
Kinases & Phosphatases
Kinases & Phosphatases
质量
Routinely evaluated by immunoblot in in NIH 3T3 cell lysates.
目标描述
130kDa
外形
ImmunoAffinity Purified
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
储存及稳定性
1 year at -20°C
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our 产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
A Petrone et al.
Journal of cell science, 113 ( Pt 13), 2345-2354 (2000-06-15)
Transmembrane (receptor) tyrosine phosphatases are intimately involved in responses to cell-cell and cell-matrix contact. Several important issues regarding the targets and regulation of this protein family are now emerging. For example, these phosphatases exhibit complex interactions with signaling pathways involving
An RPTP?/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions.
Gomez, GA; McLachlan, RW; Wu, SK; Caldwell, BJ; Moussa, E; Verma, S; Bastiani, M; Priya et al.
Molecular Biology of the Cell null
Two mechanisms activate PTPalpha during mitosis.
Zheng, X M and Shalloway, D
The Embo Journal, 20, 6037-6049 (2001)
Christine R Keenan et al.
Genome research, 34(4), 556-571 (2024-05-09)
H3K9me3-dependent heterochromatin is critical for the silencing of repeat-rich pericentromeric regions and also has key roles in repressing lineage-inappropriate protein-coding genes in differentiation and development. Here, we investigate the molecular consequences of heterochromatin loss in cells deficient in both SUV39H1
Xin-Min Zheng et al.
The Journal of biological chemistry, 277(24), 21922-21929 (2002-03-30)
During mitosis, the catalytic activity of protein-tyrosine phosphatase (PTP) alpha is enhanced, and its inhibitory binding to Grb2, which specifically blocks Src dephosphorylation, is decreased. These effects act synergistically to activate Src in mitosis. We show here that these effects
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门