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07-175

抗磷酸化-JNK (Thr183/Tyr185, Thr221/Tyr223) 抗体

Name: 抗磷酸化-JNK (Thr183/Tyr185, Thr221/Tyr223) 抗体
Brand: MM

from rabbit, purified by affinity chromatography

别名:

JNK1 alpha protein kinase, JNK1 beta protein kinase, JUN N-terminal kinase, Stress-activated protein kinase JNK1, Stress-activated protein kinase JNK1, mitogen-activated protein kinase 8, mitogen-activated protein kinase 8 isoform JNK1 alpha1, mitogen-ac

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About This Item

UNSPSC代码:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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此商品	04893	051076	SAB4502743
07175 抗磷酸化-JNK (Thr183/Tyr185, Thr221/Tyr223) 抗体	04893 Anti-JNK3/SAPK1b Antibody, clone C05T, rabbit monoclonal	051076 Anti-c-Jun Antibody, clone 6E4.4	SAB4502743 Anti-JNKK, C-Terminal antibody produced in rabbit
species reactivity human, mouse, horse	species reactivity rat, human	species reactivity mouse, human, rat	species reactivity rat, human, mouse
antibody form affinity isolated antibody	antibody form culture supernatant	antibody form purified immunoglobulin	antibody form affinity isolated antibody
clone polyclonal	clone C05T, monoclonal	clone 6E4.4, monoclonal	clone polyclonal
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
shipped in wet ice	shipped in dry ice	shipped in ambient	shipped in wet ice
UniProt accession no. P45983	UniProt accession no. P49187	UniProt accession no. P45983	UniProt accession no. P45985

一般描述

JNK1（MAPK8）是MAP激酶家族的成员。MAP激酶作为多种生化信号的整合点，参与增殖、分化、转录调控和发育等多种细胞过程。该激酶被各种细胞刺激激活，并靶向特定的转录因子，从而响应细胞刺激而介导立即早期的基因表达。发现肿瘤坏死因子α（TNF-α）激活该激酶是TNF-α诱导的细胞凋亡所必需的。该激酶也参与紫外线辐射诱导的细胞凋亡，被认为与细胞色素c介导的细胞死亡途径有关。对该基因的小鼠对应物的研究表明，该激酶在T细胞增殖，凋亡和分化中起关键作用。已经报道了编码不同亚型的四个可变剪接的转录物变体。JNK1被两个双重特异性激酶MAP2K4和MAP2K7之一的苏氨酸和酪氨酸磷酸化激活。JNK途径与糖尿病密切相关，肥胖症的水平异常升高。细胞可渗透的JNK抑制肽可能有望作为糖尿病的治疗剂。

特异性

该抗体可识别Thr183/Tyr185和Thr221/Tyr223磷酸化的JNK。

免疫原

与在Thr183/Tyr185和Thr221/Tyr223处磷酸化的人JNK相对应的KLH偶联线性肽。

表位：在Thr183/Tyr185和Thr221/Tyr223处磷酸化

应用

使用经验证可用于WB，EA & IP的抗磷酸化-JNK（Thr183/Tyr185，Thr221/Tyr223）抗体检测磷酸化-JNK（Thr183/Tyr185）。

免疫沉淀分析：10 µg先前批次对RAW264.7细胞裂解液在Thr183/Tyr185和Thr221/Tyr223磷酸化的JNK进行免疫沉淀。

研究子类别
MAP激酶

研究类别
信号传导

质量

通过蛋白质印迹法在未处理和λ磷酸酶处理的RAW264.7细胞裂解液中进行了评估。

蛋白质印迹分析：2 µg/mL的该抗体在10 µg未处理和λ磷酸酶RAW264.7细胞裂解液中检测到JNK。

目标描述

观测值〜42 kDa。在40-50 kDa之间有几种亚型

外形

亲和纯化

纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。

储存及稳定性

自收到之日起，在2-8°C条件下可稳定保存1年。

分析说明

对照
未处理和λ磷酸酶处理的RAW264.7细胞裂解液

其他说明

浓度：请参考批次特异性浓缩物的分析证书。

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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ZRB1173

Anti-phospho JNK (Thr183, Tyr185) Antibody, clone 3F7, ZooMAb^® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells

储存分类代码

10 - Combustible liquids

WGK

WGK 1

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Activation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells.

Vinicius Toledo Ribas et al.

PloS one, 7(4), e34483-e34483 (2012-04-13)

Most studies of c-Jun N-terminal Kinase (JNK) activation in retinal tissue were done in the context of neurodegeneration. In this study, we investigated the behavior of JNK during mitosis of progenitor cells in the retina of newborn rats. Retinal explants

Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells.

Yao Fong et al.

Cancer cell international, 17, 37-37 (2017-03-14)

2,9-Bis[2-(pyrrolidin-1-yl)ethoxy]-6-{4-[2-(pyrrolidin-1-yl)ethoxy] phenyl}-11H-indeno[1,2-c]quinoline-11-one (BPIQ), is a synthetic quinoline analog. A previous study showed the anti-cancer potential of BPIQ through modulating mitochondrial-mediated apoptosis. However, the effect of BPIQ on cell migration, an index of cancer metastasis, has not yet been examined. Furthermore

Cardiotoxin III inhibits proliferation and migration of oral cancer cells through MAPK and MMP signaling.

Yen, CY; Liang, SS; Han, LY; Chou, HL; Chou, CK; Lin, SR; Chiu, CC

TheScientificWorldJournal null

Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin.

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Journal of cell science, 125(Pt 22), 5288-5301 (2012-09-05)

A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by Wnt. Upregulation of Rac1 activity

Role of JNK during buccopharyngeal membrane perforation, the last step of embryonic mouth formation.

Nathalie S Houssin et al.

Developmental dynamics : an official publication of the American Association of Anatomists, 246(2), 100-115 (2016-12-30)

The buccopharyngeal membrane is a thin layer of cells covering the embryonic mouth. The perforation of this structure creates an opening connecting the external and the digestive tube which is essential for oral cavity formation. In humans, persistence of the

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抗磷酸化-JNK (Thr183/Tyr185, Thr221/Tyr223) 抗体