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Merck
CN
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文件

05-780

Sigma-Aldrich

Anti-Akt3/PKBγ Antibody, clone GMA104

clone GMA104, Upstate®, from mouse

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UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

100

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

GMA104, monoclonal

种属反应性

human

制造商/商品名称

Upstate®

技术

immunoprecipitation (IP): suitable
western blot: suitable

同位素/亚型

IgG2a

NCBI登记号

NM_005465

UniProt登记号

Q9Y243

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... AKT3(10000)

特异性

Predicted to cross-react with mouse and rat based on sequence homology.
RhoA

免疫原

peptide corresponding to amino acids 119-131 (CSPTSQIDNIGEE) of human Akt3/PKBγ

应用

Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling
This Anti-Akt3/PKBγ Antibody, clone GMA104 is validated for use in IP, WB for the detection of Akt3/PKBγ.

质量

routinely evaluated by immunoblot on RIPA lysates from Jurkat or HL-60 cells

目标描述

~60kDa

外形

Protein A purified
Buffered solution containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
Format: Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

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Conrad P Hodgkinson et al.
Biochemistry, 41(32), 10351-10359 (2002-08-07)
Protein kinase B (PKB), also known as Akt, is a serine/threonine protein kinase controlled by insulin, various growth factors, and phosphatidylinositol 3-kinase. Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation loop and a serine
The Akt isoforms are present at distinct subcellular locations.
Santi, SA; Lee, H
American Journal of Physiology. Cell Physiology null
Aroa Soriano et al.
Oncotarget, 7(8), 9271-9287 (2016-01-30)
Despite multimodal therapies, a high percentage of high-risk neuroblastoma (NB) become refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or function, activating the DNA damage response (DDR). In cancer, this process is frequently altered

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