biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
GMA104, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... AKT3(10000)
General description
~60kDa
Immunogen
peptide corresponding to amino acids 119-131 (CSPTSQIDNIGEE) of human Akt3/PKBγ
Application
Research Category
Signaling
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling
PI3K, Akt, & mTOR Signaling
This Anti-Akt3/PKBγ Antibody, clone GMA104 is validated for use in IP, WB for the detection of Akt3/PKBγ.
Biochem/physiol Actions
Predicted to cross-react with mouse and rat based on sequence homology.
RhoA
Physical form
Buffered solution containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
Format: Purified
Protein A purified
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
routinely evaluated by immunoblot on RIPA lysates from Jurkat or HL-60 cells
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
Rebekka Geißert et al.
Cell communication and signaling : CCS, 22(1), 85-85 (2024-01-31)
K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hyperactivation of effector proteins and downstream signaling pathways. Here, we
Conrad P Hodgkinson et al.
Biochemistry, 41(32), 10351-10359 (2002-08-07)
Protein kinase B (PKB), also known as Akt, is a serine/threonine protein kinase controlled by insulin, various growth factors, and phosphatidylinositol 3-kinase. Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation loop and a serine
The Akt isoforms are present at distinct subcellular locations.
Santi, SA; Lee, H
American Journal of Physiology. Cell Physiology null