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Merck
CN
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主要文件

05-747

Sigma-Aldrich

抗磷酸化MEK1（Ser218/222）/MEK2（Ser222/226）抗体（兔单克隆）

Upstate®, from rabbit

别名:

Anti-CFC3, Anti-MAPKK1, Anti-MEK1, Anti-MEL, Anti-MKK1, Anti-PRKMK1

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About This Item

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

100

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

monoclonal

种属反应性

human, mouse, rat

制造商/商品名称

Upstate®

技术

western blot: suitable

同位素/亚型

IgG

NCBI登记号

NM_002755
NM_030662

UniProt登记号

Q02750

运输

dry ice

靶向翻译后修饰

phosphorylation (pSer218/pSer222)

基因信息

human ... MAP2K1(5604)

特异性

磷酸化MEK1/MEK2

免疫原

含DpSMANpSF的肽，其中pS对应于人MEK1磷酸化氨基酸 218 和 222。

应用

使用经验证可用于WB的该抗磷酸化MEK1（Ser218/222）/MEK2（Ser222/226） 抗体来检测磷酸化MEK1（Ser218/222）/MEK2（Ser222/226） 。
研究子类别
MAP激酶
研究类别
信号传导

质量

通过免疫印迹对 B-Raf处理的PC-12细胞的 RIPA裂解液进行了常规评估

目标描述

45kDa

联系

替代：04-1017

外形

0.1M Tris-甘氨酸，pH 7.4，0.15M NaCl，0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
纯化蛋白A

储存及稳定性

在-20°C下可保存2年

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

10 - Combustible liquids

WGK

WGK 2

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Gonzalo L Gonzalez-Del Pino et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(36) (2021-09-03)
The RAF/MEK/ERK pathway is central to the control of cell physiology, and its dysregulation is associated with many cancers. Accordingly, the proteins constituting this pathway, including MEK1/2 (MEK), have been subject to intense drug discovery and development efforts. Allosteric MEK
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.
Gopalbhai, Kailesh, et al.
The Journal of Biological Chemistry, 278, 8118-8125 (2003)
Dennis M Bjorklund et al.
Biomolecules, 12(7) (2022-07-28)
The kinome specific co-chaperone, CDC37 (cell division cycle 37), is responsible for delivering BRAF (B-Rapidly Accelerated Fibrosarcoma) to the Hsp90 (heat shock protein 90) complex, where it is then translocated to the RAS (protooncogene product p21) complex at the plasma
Sigrun Polier et al.
Nature chemical biology, 9(5), 307-312 (2013-03-19)
Protein kinase clients are recruited to the Hsp90 molecular chaperone system via Cdc37, which simultaneously binds Hsp90 and kinases and regulates the Hsp90 chaperone cycle. Pharmacological inhibition of Hsp90 in vivo results in degradation of kinase clients, with a therapeutic
C Hodge et al.
The Journal of biological chemistry, 273(47), 31327-31336 (1998-11-13)
Growth hormone (GH), a major regulator of normal body growth and metabolism, regulates cellular gene expression. The transcription factors Elk-1 and Serum Response Factor are necessary for GH-stimulated transcription of c-fos through the Serum Response Element (SRE). GH stimulates the
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