05-747
抗磷酸化MEK1（Ser218/222）/MEK2（Ser222/226）抗体（兔单克隆）
Upstate®, from rabbit
别名:
Anti-CFC3, Anti-MAPKK1, Anti-MEK1, Anti-MEL, Anti-MKK1, Anti-PRKMK1
产品名称
抗磷酸化MEK1（Ser218/222）/MEK2（Ser222/226）抗体（兔单克隆）, Upstate®, from rabbit
biological source
rabbit
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
monoclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
dry ice
target post-translational modification
phosphorylation (pSer218/pSer222)
Quality Level
Gene Information
human ... MAP2K1(5604)
Analysis Note
通过免疫印迹对 B-Raf处理的PC-12细胞的 RIPA裂解液进行了常规评估
Application
使用经验证可用于WB的该抗磷酸化MEK1（Ser218/222）/MEK2（Ser222/226） 抗体来检测磷酸化MEK1（Ser218/222）/MEK2（Ser222/226） 。
研究子类别
MAP激酶
MAP激酶
研究类别
信号传导
信号传导
Biochem/physiol Actions
磷酸化MEK1/MEK2
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
45kDa
Immunogen
含DpSMANpSF的肽，其中pS对应于人MEK1磷酸化氨基酸 218 和 222。
Other Notes
替代：04-1017
Physical form
0.1M Tris-甘氨酸，pH 7.4，0.15M NaCl，0.05％叠氮化钠，然后添加甘油至30％
形式：纯化
纯化蛋白A
Preparation Note
在-20°C下可保存2年
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
Gonzalo L Gonzalez-Del Pino et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(36) (2021-09-03)
The RAF/MEK/ERK pathway is central to the control of cell physiology, and its dysregulation is associated with many cancers. Accordingly, the proteins constituting this pathway, including MEK1/2 (MEK), have been subject to intense drug discovery and development efforts. Allosteric MEK
Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1.
Gopalbhai, Kailesh, et al.
The Journal of Biological Chemistry, 278, 8118-8125 (2003)
Sigrun Polier et al.
Nature chemical biology, 9(5), 307-312 (2013-03-19)
Protein kinase clients are recruited to the Hsp90 molecular chaperone system via Cdc37, which simultaneously binds Hsp90 and kinases and regulates the Hsp90 chaperone cycle. Pharmacological inhibition of Hsp90 in vivo results in degradation of kinase clients, with a therapeutic
Dennis M Bjorklund et al.
Biomolecules, 12(7) (2022-07-28)
The kinome specific co-chaperone, CDC37 (cell division cycle 37), is responsible for delivering BRAF (B-Rapidly Accelerated Fibrosarcoma) to the Hsp90 (heat shock protein 90) complex, where it is then translocated to the RAS (protooncogene product p21) complex at the plasma
C Hodge et al.
The Journal of biological chemistry, 273(47), 31327-31336 (1998-11-13)
Growth hormone (GH), a major regulator of normal body growth and metabolism, regulates cellular gene expression. The transcription factors Elk-1 and Serum Response Factor are necessary for GH-stimulated transcription of c-fos through the Serum Response Element (SRE). GH stimulates the
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