05-666
抗BRCA2抗体，克隆5.23
clone 5.23, Upstate®, from mouse
别名:
Anti BRCC2, Anti-BROVCA2, Anti-FACD, Anti-FAD, Anti-FAD1, Anti-FANCD, Anti-FANCD1, Anti-GLM3, Anti-PNCA2, Anti-XRCC11
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
5.23, monoclonal
Application:
immunocytochemistry
western blot
western blot
Species reactivity:
human
Citations:
15
Technique(s):
immunocytochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗BRCA2抗体，克隆5.23, clone 5.23, Upstate®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
5.23, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BRCA2(675)
Analysis Note
对照
阳性抗原对照：货号12-309，HeLa细胞核提取物。添加 等体积Laemmli样品还原性缓冲液至10 μL提取物并 煮沸5分钟以还原制剂。在小型凝胶每个泳道上样20 μg 经还原的提取物。
阳性抗原对照：货号12-309，HeLa细胞核提取物。添加 等体积Laemmli样品还原性缓冲液至10 μL提取物并 煮沸5分钟以还原制剂。在小型凝胶每个泳道上样20 μg 经还原的提取物。
已通过免疫印迹法对HeLa核提取物进行常规评估
Application
用抗BRCA2抗体，克隆5.23（小鼠单克隆抗体）检测BRCA2，已证明可在WB、ICC中起作用。
研究子类别
细胞周期，DNA 复制&修复
细胞周期，DNA 复制&修复
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
BRCA2
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
390kDa
Immunogen
GST融合蛋白，对应人BRCA2蛋白的2959-3418位残基
Other Notes
由于许可协议限制，无法购买该产品进行转售。
Physical form
0.1M Tris-甘氨酸（pH 7.4），0.15M NaCl与0.05％叠氮化钠。
形式：纯化
蛋白G层析
Preparation Note
储存于2-8°C。 收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于2-8°C。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Jimmy M-M Kwok et al.
Molecular cancer research : MCR, 8(1), 24-34 (2010-01-14)
The transcription factor Forkhead box M1 (FOXM1) is a key regulator of cell proliferation and is overexpressed in many forms of primary cancers, leading to uncontrolled cell division and genomic instability. To address the role of FOXM1 in chemoresistance, we
Loredana Moro et al.
The Journal of biological chemistry, 280(23), 22482-22491 (2005-04-05)
BRCA2 is a tumor suppressor gene that when mutated confers an increased susceptibility to developing breast and prostate carcinoma. Besides its role in mediating DNA repair, new evidence suggests that BRCA2 may also play a role in suppressing cancer cell
Loredana Moro et al.
The Journal of biological chemistry, 281(31), 22100-22107 (2006-06-07)
Aberrant interaction of carcinoma cells with basement membranes (BM) is a fundamental pathophysiological process that initiates a series of events resulting in cancer cell invasion and metastasis. In this report, we describe the results of our investigations pertaining to the
Yongjun Tan et al.
Molecular and cellular biology, 27(3), 1007-1016 (2006-11-15)
The forkhead box M1 (FoxM1) transcription factor regulates expression of cell cycle genes essential for DNA replication and mitosis during organ repair and cancer progression. Here, we demonstrate that FoxM1-deficient (-/-) mouse embryonic fibroblasts and osteosarcoma U2OS cells depleted in
Karen J Ouyang et al.
Frontiers in genetics, 4, 167-167 (2013-09-13)
Polymerase stalling results in uncoupling of DNA polymerase and the replicative helicase, which generates single-stranded DNA (ssDNA). After stalling, RAD51 accumulates at stalled replication forks to stabilize the fork and to repair by homologous recombination (HR) double-strand breaks (DSBs) that
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