05-644
抗-CAR抗体，克隆RmcB
clone RmcB, Upstate®, from mouse
别名:
46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3 binding protein, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, coxsackie virus B receptor, coxsackie virus and adenovirus receptor
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
RmcB, monoclonal
Application:
ICC, WB
Citations:
56
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RmcB, monoclonal
species reactivity
human, rat, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CXADR(1525)
General description
~46 kDa
柯萨奇病毒和腺病毒受体（CAR）介导柯萨奇B病毒和许多腺病毒的细胞附着和感染。CAR还介导同型细胞间相互作用。在极化的上皮细胞中，CAR与紧密连接紧密相关，在紧密连接中，CAR有助于溶质和大分子的细胞旁流动。CAR′s的生物学作用尚不明确，但新出现的证据表明它可能在胚胎发育和调节细胞增殖中起作用。
Immunogen
天然人柯萨奇病毒-腺病毒受体蛋白。
Application
免疫细胞化学：
1-2 μg/mL先前批次在HeLa细胞，hCAR转染的CHO细胞中显示出CAR的阳性免疫染色，但在用4%多聚甲醛固定并用0.2%Triton-X透化的未转染的CHO细胞中则没有。
1-2 μg/mL先前批次在HeLa细胞，hCAR转染的CHO细胞中显示出CAR的阳性免疫染色，但在用4%多聚甲醛固定并用0.2%Triton-X透化的未转染的CHO细胞中则没有。
抗CAR抗体，克隆RmcB可检测CAR的水平 & 已出版 & 并经过验证可用于IC & WB。
Biochem/physiol Actions
识别分子量约为6 kDa的CAR。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1，溶于含有0.1M Tris甘氨酸（pH 7.4）、0.15M NaCl、0.05％叠氮化钠的缓冲液中。
Analysis Note
已通过蛋白质印迹对小鼠小肠裂解液进行了评估。
蛋白质印迹分析：
该抗体的1：500的稀释液在10 µg小鼠小肠裂解液中检测到Car。
蛋白质印迹分析：
该抗体的1：500的稀释液在10 µg小鼠小肠裂解液中检测到Car。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Estrella Lopez-Gordo et al.
Journal of virology, 91(12) (2017-04-07)
Human adenoviral serotype 5 (HAdV-5) vectors have predominantly hepatic tropism when delivered intravascularly, resulting in immune activation and toxicity. Coagulation factor X (FX) binding to HAdV-5 mediates liver transduction and provides protection from virion neutralization in mice. FX is dispensable
Y Watanabe et al.
Cancer gene therapy, 19(11), 767-772 (2012-09-08)
Replication-selective oncolytic viruses are being developed for human cancer therapy. We previously developed an attenuated adenovirus (OBP-301, Telomelysin), in which the human telomerase reverse transcriptase promoter element drives expression of E1A and E1B genes linked with an internal ribosome entry
A monoclonal antibody specific for the cellular receptor for the group B coxsackieviruses.
Hsu KH, Lonberg-Holm K, Alstein B, Crowell RL.
Journal of virology, 62, 1647-1652 (1988)
Sarah L Hulin-Curtis et al.
Oncotarget, 9(41), 26328-26341 (2018-06-15)
Ovarian cancer is often termed a silent killer due to the late onset of symptoms. Whilst patients initially respond to chemotherapy, they rapidly develop chemo-resistance. Oncolytic adenoviruses (OAds) are promising anti-cancer agents engineered to "hijack" the unique molecular machinery of
Antitumor effects of bladder cancer-specific adenovirus carrying E1A-androgen receptor in bladder cancer.
Zhai, Z; Wang, Z; Fu, S; Lu, J; Wang, F; Li, R; Zhang, H; Li, S; Hou, Z; Wang, H; Rodriguez, R
Gene Therapy null
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