05-644
抗-CAR抗体，克隆RmcB
clone RmcB, Upstate®, from mouse
别名:
46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3 binding protein, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, coxsackie virus B receptor, coxsackie virus and adenovirus receptor
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
RmcB, monoclonal
Application:
immunocytochemistry
western blot
western blot
Species reactivity:
human, rat, mouse
Citations:
56
Technique(s):
immunocytochemistry: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-CAR抗体，克隆RmcB, clone RmcB, Upstate®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RmcB, monoclonal
species reactivity
human, rat, mouse
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CXADR(1525)
Analysis Note
已通过蛋白质印迹对小鼠小肠裂解液进行了评估。
蛋白质印迹分析：
该抗体的1：500的稀释液在10 µg小鼠小肠裂解液中检测到Car。
蛋白质印迹分析：
该抗体的1：500的稀释液在10 µg小鼠小肠裂解液中检测到Car。
Application
免疫细胞化学：
1-2 μg/mL先前批次在HeLa细胞，hCAR转染的CHO细胞中显示出CAR的阳性免疫染色，但在用4%多聚甲醛固定并用0.2%Triton-X透化的未转染的CHO细胞中则没有。
1-2 μg/mL先前批次在HeLa细胞，hCAR转染的CHO细胞中显示出CAR的阳性免疫染色，但在用4%多聚甲醛固定并用0.2%Triton-X透化的未转染的CHO细胞中则没有。
抗CAR抗体，克隆RmcB可检测CAR的水平 & 已出版 & 并经过验证可用于IC & WB。
Biochem/physiol Actions
识别分子量约为6 kDa的CAR。
General description
~46 kDa
柯萨奇病毒和腺病毒受体（CAR）介导柯萨奇B病毒和许多腺病毒的细胞附着和感染。CAR还介导同型细胞间相互作用。在极化的上皮细胞中，CAR与紧密连接紧密相关，在紧密连接中，CAR有助于溶质和大分子的细胞旁流动。CAR′s的生物学作用尚不明确，但新出现的证据表明它可能在胚胎发育和调节细胞增殖中起作用。
Immunogen
天然人柯萨奇病毒-腺病毒受体蛋白。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1，溶于含有0.1M Tris甘氨酸（pH 7.4）、0.15M NaCl、0.05％叠氮化钠的缓冲液中。
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Jeffrey E Teigler et al.
Journal of virology, 86(18), 9590-9598 (2012-07-13)
Adenovirus (Ad) vaccine vectors have proven highly immunogenic in multiple experimental models, but the innate immune responses induced by these vectors remain poorly characterized. Here we report innate cytokine responses to 5 different Ad vectors in 26 rhesus monkeys. Vaccination
William C Adams et al.
The Journal of general virology, 90(Pt 7), 1600-1610 (2009-03-14)
The coxsackievirus-adenovirus receptor (CAR) is the described primary receptor for adenovirus serotype 5 (Ad5), a common human pathogen that has been exploited as a viral vector for gene therapy and vaccination. This study showed that monocytes and dendritic cells (DCs)
A monoclonal antibody specific for the cellular receptor for the group B coxsackieviruses.
Hsu KH, Lonberg-Holm K, Alstein B, Crowell RL.
Journal of virology, 62, 1647-1652 (1988)
Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance.
Othman, M; Labelle, A; Mazzetti, I; Elbatarny, HS; Lillicrap, D
Blood null
Estrella Lopez-Gordo et al.
Journal of virology, 91(12) (2017-04-07)
Human adenoviral serotype 5 (HAdV-5) vectors have predominantly hepatic tropism when delivered intravascularly, resulting in immune activation and toxicity. Coagulation factor X (FX) binding to HAdV-5 mediates liver transduction and provides protection from virion neutralization in mice. FX is dispensable
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