SMC^®淀粉样蛋白1-40高灵敏度免疫分析试剂盒

Amyloid Beta 1-40 (Aβ1-40) is a peptide that arises from the proteolytic cleavage of the amyloid precursor protein (APP), a transmembrane protein thought to be involved in neuronal development and function. Aβ1-40 is one of the most common isoforms generated from APP, alongside Aβ1-42, which is more toxic and associated with the formation of amyloid plaques in neurodegenerative diseases.
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.

Neuroscience/Neurological Disorders/Signaling

Although Amyloid Beta 40 was detectable in mouse and rat samples, the assay has not been verified for these species.

96 well assay

• Sensitivity: LLOQ 5,860 fg/mL* (SMCxPRO^® instrument
• Standard Curve Range: 340-350,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <10%
• Linearity: Plasma: 104% CSF: 109%
• Recovery: Plasma 110% CSF: 100%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Neuroscience Neurological Disorders Neurodegenerative Diseases Alzheimer′s Disease

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SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

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