推荐产品
等级
certified reference material
质量水平
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
100 μg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
格式
single component solution
储存温度
−20°C
SMILES字符串
OC1=CC=C(C(CN(C)C)C2(O)CCCCC2)C=C1
InChI
1S/C16H25NO2/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,18-19H,3-5,10-12H2,1-2H3
InChI key
KYYIDSXMWOZKMP-UHFFFAOYSA-N
基因信息
human ... SLC6A2(6530) , SLC6A4(6532)
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一般描述
An analytical reference standard applicable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications such as urine drug testing, forensic analysis, or clinical toxicology. Also known as desvenlafaxine, O-desmethylvenlafaxine is an SNRI antidepressant marketed under the trade name Pristiq® for the treatment of depression. O-desmethylvenlafaxine is also a major urinary metabolite of venlafaxine, an SNRI antidepressant sold as Effexor® or Efexor and used to treat major depressive disorder, generalized anxiety disorder, and other anxiety disorders associated with depression.
应用
- Drug Stability in Pharmaceutical Formulations: Another study focused on the physical stability and solubility of O-Desmethylvenlafaxine in various pharmaceutical formulations, contributing to better drug delivery systems and enhanced therapeutic efficacy (Wang et al., 2020).
- Monitoring Drug Precursors in Advanced Treatment Processes: Research monitored N-nitrosodimethylamine (NDMA) precursors throughout membrane-based advanced wastewater treatment processes, considering the behavior of compounds like O-Desmethylvenlafaxine. This study aids in improving wastewater treatment strategies to mitigate pharmaceutical pollutants (Roccaro et al., 2020).
- Chiral Drug Analysis in Environmental Waters: A study developed a dual enantioselective LC-MS/MS method for analyzing chiral drugs in surface water, including O-Desmethylvenlafaxine. This method helps in understanding the environmental fate and behavior of chiral pharmaceuticals, enhancing environmental risk assessments (Coelho et al., 2019).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Effexor is a registered trademark of American Home Product Corp.
Pristiq is a registered trademark of Wyeth LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
WGK
WGK 1
闪点(°F)
49.5 °F
闪点(°C)
9.7 °C
法规信息
危险化学品
S Unterecker et al.
Pharmacopsychiatry, 45(6), 229-235 (2012-03-20)
Venlafaxine (VEN) is a modern antidepressant which exerts both serotonin and norepinephrine reuptake inhibition. In this study we examined the influence of age, sex, smoking, and co-medication on serum levels of VEN and its metabolite O-desmethylvenlafaxine (ODVEN) in patients treated
David F Archer et al.
Menopause (New York, N.Y.), 20(1), 47-56 (2012-12-26)
A previous trial of the serotonin-norepinephrine reuptake inhibitor desvenlafaxine (administered as desvenlafaxine succinate) raised concerns on potential serious cardiovascular and hepatic events. The current study was designed to estimate these events in desvenlafaxine versus placebo in a larger population followed
Paola C Rúa-Gómez et al.
Journal of environmental monitoring : JEM, 14(5), 1391-1399 (2012-03-27)
The presence of the anesthetic lidocaine (LDC), the analgesic tramadol (TRA), the antidepressant venlafaxine (VEN) and the metabolites O-desmethyltramadol (ODT) and O-desmethylvenlafaxine (ODV) was investigated in wastewater treatment plant (WWTP) effluents, in surface waters and in groundwater. The analytes were
Andrea Cipriani et al.
The Cochrane database of systematic reviews, 10, CD006533-CD006533 (2012-10-19)
Although pharmacological and psychological interventions are both effective for major depression, in primary and secondary care settings antidepressant drugs remain the mainstay of treatment. Amongst antidepressants many different agents are available. Duloxetine hydrochloride is a dual reuptake inhibitor of serotonin
Christopher J A Neil et al.
Heart, lung & circulation, 21(4), 203-205 (2012-01-31)
Tako-Tsubo cardiomyopathy (TTC) occurs particularly in post-menopausal women, being precipitated in many cases by severe emotional stress. We describe six patients in whom TTC occurred in association with therapeutic ingestion or overdose of the serotonin/noradrenaline reuptake inhibitor venlafaxine, or its
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